Article No
30-1776-100
Application | FC |
Article No | 30-1776-100 |
Country Availability | SE, FI, DK, NO, IS, EE, LV, LT |
Clone | 10.1 |
Clone Type | monoclonal |
Conjugation | APC |
Description | APC Conjugated, Anti-CD64 / FcgammaRI Monoclonal Antibody (Clone:10.1) |
Supplier | Abeomics |
Entrez Gene ID | 2209 |
Gene Symbol | FCGR1A |
Immunogen | Rheumatoid synovial fluid cells and fibronectin purified human monocytes |
Isotype | IgG1 |
Notes | CD64 (FcgammaRI) is a cell surface receptor for Fc region of IgG. It is composed of specific ligand binding alpha subunit and promiscuous gamma subunit, which is indispensable for tyrosine-based signaling. However, even the alpha subunit can transduce signals leading to cellular effector functions. The isoform FcgammaRIa1 binds human IgG with high affinity, has limited myeloid cell distribution, and a relatively large intracellular domain. Products of related genes include FcgammaRIb and FcgammaRIc isoforms, but these specify low affinity IgG receptors if functionally expressed at all. Besides a role in antigen clearance, FcgammaRI (a1) can potently enhance MHC class I and II antigen presentation in vitro and in vivo. |
Alias Names | FCGR1A||FCG1||FCGR1||IGFR1 |
Product Type | Antibodies Primary |
Shipping Information | Blue Ice |
Size | 100 Tests |
Source / Host | mouse |
Species Reactivity | human |
Storage | 4°C |
UniProt Number | P12314 |
Product Page Updated | 2024-02-06T07:35:53.072Z |