Article No
30-1910-0.1
Application | FC, ICC, IP, WB |
Article No | 30-1910-0.1 |
Country Availability | SE, FI, DK, NO, IS, EE, LV, LT |
Clone | L17F12 |
Clone Type | monoclonal |
Conjugation | Biotin |
Description | Anti-CD5 Monoclonal Antibody (Clone:L17F12)-Biotin Conjugated |
Supplier | Abeomics |
Entrez Gene ID | 921 |
Gene Symbol | CD5 |
Immunogen | Human acute lymphoblastic leukemia (ALL) T cells |
Isotype | IgG2a |
Notes | CD5 antigen (T1; 67 kDa) is a human cell surface T-lymphocyte single-chain transmembrane glycoprotein. CD5 is expressed on all mature T-lymphocytes, most of thymocytes, subset of B-lymphocytes and on many T-cell leukemias and lymphomas. It is a type I membrane glycoprotein whose extracellular region contains three scavenger receptor cysteine-rich (SRCR) domains.The CD5 is a signal transducing molecule whose cytoplasmic tail is devoid of any intrinsic catalytic activity. CD5 modulates signaling through the antigen-specific receptor complex (TCR and BCR). CD5 crosslinking induces extracellular Ca++ mobilization, tyrosine phosphorylation of intracellular proteins and DAG production. Preliminary evidence shows protein associations with ZAP-70, p56lck, p59fyn, PC-PLC, etc. CD5 may serve as a dual receptor, giving either stimulatory or inhibitory signals depending both on the cell type and development stage. In thymocytes and B1a cells seems to provide inhibitory signals, in peripheral mature T lymhocytes it acts as a costimulatory signal receptor. CD5 is the phenotypic marker of a B cell subpopulation involved in the production of autoreactive antibodies.Disease relevance: CD5 is a phenotypic marker for some B cell lymphoproliferative disorders (B-CLL, Hairy cell leukemia, etc.). The CD5+ popuation is expanded in some autoimmune disorders (Rheumatoid Arthritis, etc.). Herpes virus infections induce loss of CD5 expression in the expanded CD8+ human T cells. |
Alias Names | CD5||LEU1 |
Product Type | Antibodies Primary |
Shipping Information | Blue Ice |
Size | 0.1 mg |
Source / Host | mouse |
Species Reactivity | human |
Storage | 4°C |
UniProt Number | P06127 |
Product Page Updated | 2024-02-06T07:35:53.072Z |