14-3-3 theta/tau

Article No 303-X1010
Product Type Antibodies Primary
Research Area Cell Death
Application ELISA, WB
Size 100 µg

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Specifications

Country Availability SE, FI, DK, NO, EE, LV, LT
Clone 3B9
Clone Type monoclonal
Concentration See vial for concentration
Conjugation Unconjugated
Control Tissue 3T3, PC12, Jurkat
Data Sheet Link http://www.exalpha.com/datasheets/X1010.pdf
Description Mouse anti Human 14-3-3 theta/tau
Supplier Exalpha Biologicals
Immunogen Recombinant 14-3-3 / protein
Isotype IgG1
Notes At least seven isoforms comprise the highly conserved 14-3-3 family of homo- and heterodimeric proteins that are abundantly expressed in all eukaryotic cells. Although more than seven isoforms of 14-3-3 have been described, some redundancies have appeared upon sequencing. The 14-3-3s are thought to be key regulators of signal transduction events mediated through their binding to serine-phosphorylated proteins. By interacting with Cdc25C, 14-3-3 regulates entry into the cell cycle and, through interaction with Bad, prevents apoptosis. Other proteins that have been shown to bind to 14-3-3s include members of the protein kinase C family, Cbl, IRS-1, polyoma middle-T antigen, nitrate reductase, S-raf and the IGF-1 receptor. Detection of 14-3-3 proteins in cerebrospinal fluid has been shown to be quite useful in the differential diagnosis of Creutzfeldt-Jakob disease and other prion diseases.
Alias Names mouse anti 14-3-3 theta/tau, theta tau
Purification Protein A/G Chromatography
References 1. Umahara, T., et al. 'Structure-oriented review of 14-3-3 protein isoforms in geriatric neuroscience.' Geriatr. Gerontol. Int. 2012, epub. 2. Choi, M.R., et al. 'Effect of fluoxetine on the expression of tryptophan hydroxylase and 14-3-3 protein in the dorsal raphe nucleus and hippocampus of rat.' J. Chem. Neuronat., 2012, 43, 96-102 3. Obsil, T., et al. 'Structural basis of 14-3-3 protein function.' Semin. Cell Dev. Biol. 2011, 22, 663-672.
Size 100
Size Unit µg
Source / Host mouse
Species Reactivity human, mouse, rat, cow/bovine
Storage Product should be stored at -20ºC. Aliquot to avoid freeze/thaw cycles
Substrate / Buffer Provided as sterile filtered solution containing 20 mM sodium phosphate, 150 mM sodium chloride, 50% glycerol at pH 7.5 and 3 mM sodium azide
Technical Specifications Clone 3B9 anti-14-3-3θ/τ reacts specifically with the θ/τ isoform and does not react with 14-3-3ζ .Optimal concentration should be evaluated by serial dilutions.
UniProt Number P27348
Product Page Updated 2019-01-09T10:09:28.847Z

Shipping info

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Source/Host:

mouse mouse

Species reactivity:

human, mouse, rat, cow/bovine human mouse rat

Product insert:

Product data sheet

Datasheet

Suggested protocols:

Western Blot

Western Blot