Article No
345047
Application | PG |
Article No | 345047 |
Country Availability | SE, FI, DK, NO, IS, EE, LV, LT, FO, GL |
Clone | F38-2E2 |
Clone Type | monoclonal |
Conjugation | TotalSeq-A |
Description | TotalSeq™-A0169 anti-human CD366 (Tim-3) |
Supplier | BioLegend |
Isotype | IgG1 k |
Notes | CD366 (Tim-3) is a transmembrane protein also known as T cell immunoglobulin and mucin domain containing protein-3. Tim-3 is expressed at high levels on activated T cells (preferentially on Th1 cells, monocytes/macrophages, and dendritic cells). Tim-3 has also been shown to exist as a soluble protein. Cells expressing Tim-3 are present at high levels in the CNS of animals at the onset of experimental autoimmune encephalomyelitis (EAE), a disease mediated by lymphocytes secreting Th1-like cytokines. Tim-3 has been proposed to inhibit Th1-mediated immune responses and promote immunological tolerance. |
Alias Names | T cell immunoglobulin and mucin domain containing protein 3, hepatitis virus cellular receptor 2, CD366 |
Product Type | Antibodies Primary |
Research Area | Immunology |
Shipping Information | Ambient RT |
Size | 10 µg |
Source / Host | mouse |
Species Reactivity | human |
Storage | 2°C-8°C |
Product Page Updated | 2024-03-04T15:03:13.794Z |