Article No
35-1877-100
Specifications
| Application | ELISA, IHC, WB |
| Article No | 35-1877-100 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT |
| Clone Type | polyclonal |
| Description | ACE2 Antibody |
| Supplier | Abeomics |
| Entrez Gene ID | 59272 |
| Gene Symbol | ACE2 |
| Immunogen | This Antibody was raised against a synthetic peptide corresponding to amino acids near the C-terminus of human ACE2. |
| Isotype | IgG |
| Notes | Angiotensin-converting enzyme 2 (ACE2) plays a central role in vascular, renal, and myocardial physiology. In contrast to its homolog ACE, ACE2 expression is restricted to heart, kidney, and testis. Recently. ACE2 has also been shown to be a functional receptor of the SARS coronavirus. The normal function of ACE2 is to convert the inactive vasoconstrictor angiotensin I (AngI) to Ang1-9 and the active form AngII to Ang1-7, unlike ACE, which converts AngI to AngII. While the role of these vasoactive peptides is not well understood, lack of ACE2 expression in ace2-/ace2- mice leads to severely reduced cardiac contractility, indicating its importance in regulating heart function. |
| Alias Names | ACEH antibody; DKFZp434A014 antibody; ACE2 antibody; metalloprotease MPROT15 antibody; angiotensin-converting enzyme homolog antibody; angiotensin I converting enzyme 2 antibody; ACE-related carboxypeptidase antibody; angiotensin-converting enzyme 2 antibody |
| Product Type | Antibodies Primary |
| Protocol | Western blotting analysis: 0.5-2 µg/ml, Immunohistochemical analysis-2-4 µg/ml |
| Purification | Affinity Purified |
| Research area | Cell Signaling |
| Size | 100 µl |
| Source / Host | rabbit |
| Species Reactivity | human |
| Storage | -20°C |
| Substrate / Buffer | Supplied in PBS containing 0.02% sodium azide. |
| UniProt Number | Q9BYF1 |
| Product Page Updated | 2024-02-06T07:35:53.072Z |
