Article No
36-3407-20
Application | IHC |
Article No | 36-3407-20 |
Country Availability | SE, FI, DK, NO, IS, EE, LV, LT |
Clone | 93 |
Clone Type | monoclonal |
Conjugation | Unconjugated |
Description | Anti-Alpha Actinin 4 / ACTN4 Monoclonal Antibody(Clone: 93) |
Supplier | Abeomics |
Entrez Gene ID | 81 |
Gene Symbol | ACTN4 |
Immunogen | Recombinant full-length human ACTN4 protein |
Isotype | IgG |
Notes | The spectrin gene family encodes a diverse group of cytoskeletal proteins that include spectrins, dystrophins and -actinins. There are four tissue-specific -actinins, namely -actinin-1, -actinin-2, -actinin-3 and -actinin-4, which are localized to muscle and non-muscle cells, including skeletal, cardiac and smooth muscle cells, as well as within the cytoskeleton. Each -actinin protein contains one Actin-binding domain, two calponin-homology domains, two EF-hand domains and four spectrin repeats, throµgh which they function as bundling proteins that can cross-link F-Actin, thus anchoring Actin to a variety of intracellular structures. Defects in the gene encoding -actinin-4 are the cause of focal segmental glomerulosclerosis 1 (FSGS1), a common renal lesion characterized by decreasing kidney function and, ultimately, renal failure. |
Alias Names | F-actin cross-linking protein; Focal segmental glomerulosclerosis 1 (FSG1); Non-muscle alpha-actinin-4 |
Product Type | Antibodies Primary |
Protocol | Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes) |
Shipping Information | Blue Ice |
Size | 20 µg |
Source / Host | mouse |
Species Reactivity | human |
Storage | 4°C, -80°C |
Substrate / Buffer | 200 µg/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml. |
UniProt Number | O43707 |
Product Page Updated | 2024-02-06T07:35:53.072Z |