Article No
A-2742-100
MTA2 Polyclonal Antibody
MTA2 Polyclonal Antibody
Antibodies Primary
Specifications
| Application | WB, ChIP |
| Article No | A-2742-100 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT, GL |
| Clone Type | polyclonal |
| Conjugation | Unconjugated |
| Description | MTA2 Polyclonal Antibody |
| Supplier | Epigentek |
| Format | Affinity Purified |
| Gene Symbol | MTA2 |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 60-180 of human MTA2 (NP_004730.2) |
| Isotype | IgG |
| Keywords | Chromatin Remodeling , Histone Acetylation & Deacetylation |
| Notes | MTA2 (metastasis-associated protein) is a component of NuRD, a nucleosome remodeling deacetylase complex found in the nucleus of human cells. It demonstrates a very wide expression pattern and is highly expressed in various tissues. MTA2 represents only a single member of a small gene family that encode distinctive but related proteins involved in transcriptional regulation (either directly or indirectly). Chromatin remodeling may be an indirect effect of their transcriptional regulation. MTA2 is very similar to and shares domain types with another member of this family, a protein associated with metastatic carcinomas potential. The shared domains include two DNA binding domains, a dimerization domain, and a domain generally found in proteins that methylate DNA. A target protein for this gene is p53, and deacetylation of p53 is associated with reduced growth inhibition in transformed cells, thus indicating a role for these gene family members in metastasis. |
| Alias Names | PID, MTA1L1 |
| Product Type | Antibodies Primary |
| Purity | Affinity Purified |
| Research area | Epigenetics |
| Shipping Information | Shipped at 4°C. Upon receipt, store at -20°C. Avoid repeated freeze. |
| Size | 100 µl |
| Source / Host | rabbit |
| Species Reactivity | human, mouse, rat |
| Storage | Shipped at 4°C. Upon receipt, store at -20°C. Avoid repeated freeze. |
| Substrate / Buffer | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| UniProt Number | O94776 |
| Product Page Updated | 2024-02-13T10:42:34.821Z |
