Article No
A50947-050
ACKR1 Polyclonal Antibody, FITC Conjugated
ACKR1 Polyclonal Antibody, FITC Conjugated
Antibodies Primary
Specifications
| Application | ELISA |
| Article No | A50947-050 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT, GL |
| Clone Type | polyclonal |
| Conjugation | FITC |
| Description | ACKR1 Polyclonal Antibody, FITC Conjugated |
| Supplier | Epigentek |
| Immunogen | Recombinant Human Atypical chemokine receptor 1 protein (1-63AA) |
| Isotype | IgG |
| Keywords | Immunology & Inflammation |
| Notes | Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine-binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1, TARC and also for the malaria parasites P. vivax and P. knowlesi. May regulate chemokine bioavailability and, consequently, leukocyte recruitment through two distinct mechanisms: when expressed in endothelial cells, it sustains the abluminal to luminal transcytosis of tissue-derived chemokines and their subsequent presentation to circulating leukocytes; when expressed in erythrocytes, serves as blood reservoir of cognate chemokines but also as a chemokine sink, buffering potential surges in plasma chemokine levels. _x000D_ |
| Alias Names | Atypical chemokine receptor 1, Duffy antigen/chemokine receptor, Glycoprotein D, Plasmodium vivax receptor, ACKR1, DARC, FY, GPD |
| Product Type | Antibodies Primary |
| Purity | Protein G purified |
| Research area | Immunology |
| Size | 50 µl |
| Source / Host | rabbit |
| Species Reactivity | human |
| Storage | Shipped at 4°C. Upon delivery aliquot and store at -20°C (short-term) or -80°C (long-term). Avoid repeated freeze. |
| Substrate / Buffer | 0.03% Proclin 300, 50% Glycerol, 0.01M PBS, PH 7.4 |
| UniProt Number | Q16570 |
| Product Page Updated | 2024-02-13T10:42:34.821Z |
