Article No
A55482-100
ATG3 Polyclonal Antibody, Biotin Conjugated
ATG3 Polyclonal Antibody, Biotin Conjugated
Antibodies Primary
Specifications
| Application | ELISA |
| Article No | A55482-100 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT, GL |
| Clone Type | polyclonal |
| Conjugation | Biotin |
| Description | ATG3 Polyclonal Antibody, Biotin Conjugated |
| Supplier | Epigentek |
| Immunogen | Recombinant Human Ubiquitin-like-conjugating enzyme ATG3 protein (1-314AA) |
| Isotype | IgG |
| Keywords | Apoptosis & Cell Death |
| Notes | E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt), autophagy, and mitochondrial homeostasis. Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C-terminal Gly of ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A). The ATG12-ATG5 conjugate plays a role of an E3 and promotes the transfer of ATG8-like proteins from ATG3 to phosphatidylethanolamine (PE). This step is required for the membrane association of ATG8-like proteins. The formation of the ATG8-phosphatidylethanolamine conjugates is essential for autophagy and for the cytoplasm to vacuole transport (Cvt). Preferred substrate is MAP1LC3A. Also acts as an autocatalytic E2-like enzyme, catalyzing the conjugation of ATG12 to itself, ATG12 conjugation to ATG3 playing a role in mitochondrial homeostasis but not in autophagy. ATG7 (E1-like enzyme) facilitates this reaction by forming an E1-E2 complex with ATG3. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway. |
| Alias Names | Autophagy-related protein 3, APG3-like, hApg3, Protein PC3-96, ATG3, APG3, APG3L |
| Product Type | Antibodies Primary |
| Purity | Protein G purified |
| Research area | Cell Death |
| Size | 100 µl |
| Source / Host | rabbit |
| Species Reactivity | human |
| Storage | Shipped at 4°C. Upon delivery aliquot and store at -20°C (short-term) or -80°C (long-term). Avoid repeated freeze. |
| Substrate / Buffer | 0.03% Proclin 300, 50% Glycerol, 0.01M PBS, PH 7.4 |
| UniProt Number | Q9NT62 |
| Product Page Updated | 2024-02-13T10:42:34.821Z |
