Article No
A56759-050
Application | ELISA, WB, IHC, IF |
Article No | A56759-050 |
Country Availability | SE, FI, DK, NO, IS, EE, LV, LT, GL |
Clone Type | polyclonal |
Conjugation | Unconjugated |
Description | AIFM1 Polyclonal Antibody |
Supplier | Epigentek |
Immunogen | Recombinant Human Apoptosis-inducing factor 1, mitochondrial protein (103-612AA) |
Isotype | IgG |
Keywords | Apoptosis & Cell Death |
Notes | Functions both as NADH oxidoreductase and as regulator of apoptosis. In response to apoptotic stimuli, it is released from the mitochondrion intermembrane space into the cytosol and to the nucleus, where it functions as a proapoptotic factor in a caspase-independent pathway. In contrast, functions as an antiapoptotic factor in normal mitochondria via its NADH oxidoreductase activity. The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i. e. caspase-independent fragmentation of chromosomal DNA. Interacts with EIF3G,and thereby inhibits the EIF3 machinery and protein synthesis, and activates casapse-7 to amplify apoptosis. Plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells. Binds to DNA in a sequence-independent manner. |
Alias Names | Programmed cell death protein 8, AIFM1, AIF, PDCD8 |
Product Type | Antibodies Primary |
Purity | Protein G purified |
Research Area | Cell Death |
Size | 50 µl |
Source / Host | rabbit |
Species Reactivity | human |
Storage | Shipped at 4°C. Upon delivery aliquot and store at -20°C (short-term) or -80°C (long-term). Avoid repeated freeze. |
Substrate / Buffer | 0.03% Proclin 300, 50% Glycerol, 0.01M PBS, PH 7.4 |
UniProt Number | O95831 |
Product Page Updated | 2024-02-13T10:42:34.821Z |