Article No
A64438-050
Fusion Glycoprotein F0 Polyclonal Antibody
Fusion Glycoprotein F0 Polyclonal Antibody
Antibodies Primary
Specifications
| Application | ELISA |
| Article No | A64438-050 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT, GL |
| Clone Type | polyclonal |
| Conjugation | Unconjugated |
| Description | Fusion Glycoprotein F0 Polyclonal Antibody |
| Supplier | Epigentek |
| Format | Protein G Purified |
| Immunogen | Recombinant Human respiratory syncytial virus A Fusion glycoprotein F0 protein (27-529AA) |
| Isotype | IgG |
| Keywords | Immunology & Inflammation |
| Notes | During virus entry, induces fusion of viral and cellular membranes leading to delivery of the nucleocapsid into the cytoplasm. The fusogenic activity is inactive untill entry into host cell endosome, where a furin-like protease cleaves off a small peptide between F1 and F2 (PubMed:18216092). Interacts directly with heparan sulfate and may participates in virus attachment (PubMed:10864656). Furthermore, the F2 subunit was identifed as the major determinant of RSV host cell specificity (PubMed:11493675). Later in infection, proteins F expressed at the plasma membrane of infected cells can mediate fusion with adjacent cells to form syncytia, a cytopathic effect that could lead to tissue necrosis. The fusion protein is also able to trigger p53-dependent apoptosis (PubMed:12663767). |
| Alias Names | Fusion glycoprotein F0, Protein FCleaved into the following 4 chains:Fusion glycoprotein F2'1, F |
| Product Type | Antibodies Primary |
| Purity | Protein G purified |
| Research area | Immunology |
| Size | 50 µl |
| Source / Host | rabbit |
| Species Reactivity | virus |
| Storage | Shipped at 4°C. Upon delivery aliquot and store at -20°C (short-term) or -80°C (long-term). Avoid repeated freeze. |
| Substrate / Buffer | 0.03% Proclin 300, 50% Glycerol, 0.01M PBS, PH 7.4 |
| UniProt Number | P03420 |
| Product Page Updated | 2024-02-13T10:42:34.821Z |
