Article No
AC-0011
Specifications
| Application | IHC |
| Article No | AC-0011 |
| Country Availability | SE, FI, DK, NO, IS, FO, GL |
| Clone | EP4 |
| Clone Type | monoclonal |
| Conjugation | Unconjugated |
| Description | Cytokeratin 4 |
| Supplier | Cell Marque (Epitomics) |
| Format | Concentrate |
| Notes | Cytokeratin 4 (CK4) is a 59 kDa intermediate filament protein associated with cytokeratin 13. It is expressed in suprabasal cells of non-keratinized stratified squamous epithelium of esophagus, cornea, anus, larynx, pharynx and tongue. A mutation in CK4 gene causes white sponge nevus. A decreased expression of CK4 is associated with head and neck squamous carcinoma. It is helpful in differentiation of squamous cell carcinoma of esophagus origin from thyroid origin. |
| Product Type | Antibodies Primary |
| Protocol | IHC: 1:100-200 |
| Research area | Clinical Diagnostic |
| Size | 1 mL |
| Source / Host | rabbit |
| Species Reactivity | human |
| Storage | Store at 2-8 °C. Don’t use after expiration date provided on the vial. The users must validate any storage conditions other than those specified. |
| Substrate / Buffer | Antibody to Cytokeratin 4 is affinity purified and diluted in 10 mM Phosphate buffered saline (PBS), pH 7.2 containing 1% bovine serum albumin (BSA) and 0.09% sodium azide (NaN3). |
| Technical Specifications | This antibody gives cytoplasmic staining in positive cells. The recommended positive controls are Esophagus for normal tissue and Cervical squamous carcinoma for abnormal tissue. Interpretation of the staining result should be combined with an established clinical product or procedure. |
| Product Page Updated | 2023-10-02T09:48:37.458Z |
