Article No
AC-0044
Specifications
| Application | IHC |
| Article No | AC-0044 |
| Country Availability | SE, FI, DK, NO, IS, FO, GL |
| Clone | EP44 |
| Clone Type | monoclonal |
| Conjugation | Unconjugated |
| Description | CD44 |
| Supplier | Cell Marque (Epitomics) |
| Format | Concentrate |
| Notes | CD44 is a cell-surface glycoprotein postulated to play a role in a variety of biological processes, including cell-to-cell and cell-to-matrix adhesion, lymphocyte homing and tumor cell metastasis. Several isoforms of CD44 have been identified in human cells, and the genesis of some of these isoforms has been attributed to alternative splicing. Understanding of mechanisms regulating CD44 alternative splicing may provide insights into diverse processes, including tumor-cell metastasis and lymphocyte homing. CD44 is widely expressed on many types of cells with mesodermal and hematopoietic origin, epithelial cells and a variety of tumors derived from these cells. Loss of CD44 expression has been linked to tumor invasion, metastasis and progression in carcinomas of breast, prostate, lung, ovary and malignant melanoma. |
| Product Type | Antibodies Primary |
| Protocol | IHC: 1:100-200 |
| Research area | Clinical Diagnostic |
| Size | 1 mL |
| Source / Host | rabbit |
| Species Reactivity | human |
| Storage | Store at 2-8 °C. Don’t use after expiration date provided on the vial. The users must validate any storage conditions other than those specified. |
| Technical Specifications | Antibody to CD44 is affinity purified and diluted in 10 mM Phosphate buffered saline (PBS), pH 7.2 containing 1% bovine serum albumin (BSA) and 0.09% sodium azide (NaN3). This antibody gives membrane staining in positive cells. The recommended positive controls are Tonsil for normal tissue and Breast carcinoma for abnormal tissue. Interpretation of the staining result should be combined with an established clinical product or procedure. |
| Product Page Updated | 2023-10-02T09:48:37.458Z |
