Article No
AC-0064
Application | IHC |
Article No | AC-0064 |
Country Availability | SE, FI, DK, NO, IS, FO, GL |
Clone | EP67 |
Clone Type | monoclonal |
Conjugation | Unconjugated |
Description | Cytokeratin 6 |
Supplier | Cell Marque (Epitomics) |
Format | Concentrate |
Notes | The human type II Cytokeratin 6 (CK6; 56 kDa) is well known for its strong induction in stratified epithelia that feature an enhanced cell proliferation rate or abnormal differentiation during wound healing, in several diseases (e.g. psoriasis, actinic keratosis) and in cancer. CK6 is expressed on stratified epithelia including oral mucosa, esophagus, basal layer of epidermis, the outer root sheath of hair follicles, and in glandular epithelia. CK6 is a marker of hyperproliferative and activated keratinocytes found in psoriasis. CK6 paired with CK5 is useful to differentiate mesothelioma (positive) from lung carcinoma (negative) or metastatic carcinoma (negative) in the pleura. CK5/6 has also been used to distinguish usual ductal hyperplasia of the breast (strong staining) from solid papillary DCIS (negative). |
Product Type | Antibodies Primary |
Protocol | IHC: 1:100-200 |
Research Area | Clinical Diagnostic |
Size | 1 mL |
Source / Host | rabbit |
Species Reactivity | human |
Storage | Store at 2-8 °C. Don’t use after expiration date provided on the vial. The users must validate any storage conditions other than those specified. |
Substrate / Buffer | Antibody to CK6 is affinity purified and diluted in 10 mM Phosphate buffered saline (PBS), pH 7.2 containing 1% bovine serum albumin (BSA) and 0.09% |
Technical Specifications | This antibody gives cytoplasmic/membrane staining in positive cells. The recommended positive controls are Skin for normal tissue and Squamous cell carcinoma for abnormal tissue. Interpretation of the staining result should be combined with an established clinical product or procedure. |
Product Page Updated | 2023-10-02T09:48:37.458Z |