Article No
AC-0098RUO
Application | IHC |
Article No | AC-0098RUO |
Country Availability | SE, FI, DK, NO, IS, FO, GL |
Clone | EP94 |
Clone Type | monoclonal |
Conjugation | Unconjugated |
Description | Bcl-x for Research Use Only |
Supplier | Cell Marque (Epitomics) |
Format | Concentrate |
Notes | Bcl-x, also know as Bcl-2-like protein 1, is a member of the Bcl-2 protein family. It inhibits cell death, or apoptosis. Bcl-x is expressed as two isomeric forms, Bcl-xL and Bcl-xS, and it is typically present in the cytosol in association with the mitochondrial membrane. Bcl-xL forms heterodimers with various proteins, including Bax, Bak and Bcl-2. It has been found that heterodimerization with Bax does not seem to be required for anti-apoptotic activity. Since Bcl-xL can form an ion channel in synthetic lipid membranes, there is a strong possibility that this property plays a role in heterodimerizationindependent cell survival. The Bcl-X(S) isoform promotes apoptosis. Bcl-x is expressed in many types of cell including lymphocytes, neuronal cells, and epithelial cells. In tumors, a high level of Bcl-x has been found in Reed Sternberg cells in Hodgkin’s disease. Overexpression of Bcl-x has been observed in primary central nervous system lymphomas that occur in immunosuppressed patients. In prostate cancer, Bcl-x expression is increased during tumor progression. Overexpression of Bcl-x in colon cancer has been linked to a poor prognosis. |
Product Type | Antibodies Primary |
Protocol | IHC: 1:100-200 |
Research Area | Cell Death |
Size | 0.1 mL |
Source / Host | rabbit |
Species Reactivity | human |
Storage | Store at 2-8 °C. Don’t use after expiration date provided on the vial. The users must validate any storage conditions other than those specified. |
Product Page Updated | 2023-10-02T09:48:37.458Z |