Article No
AC-0196
Application | IHC |
Article No | AC-0196 |
Country Availability | SE, FI, DK, NO, IS, FO, GL |
Clone | EP136 |
Clone Type | monoclonal |
Conjugation | Unconjugated |
Description | Aurora B |
Supplier | Cell Marque (Epitomics) |
Format | Concentrate |
Notes | The serine/threonine protein kinase aurora B (Aurora B) is a chromosomal passenger protein critical for accurate chromosome segregation, cytokinesis, protein localization to the centromere and kinetochore, correct microtubule-kinetochore attachment, and regulation of the mitotic checkpoint. Aurora B forms a tight complex with inner centrosome protein and survivin Inactivation of any of these proteins causes similar defects in chromosome segregation. A significant overexpression of Aurora B has been found in a variety of human tumors including non-small cell lung carcinoma, astrocytoma, seminoma and carcinomas of the colon, prostate, endometrium and thyroid. The expression level of Aurora B is associated with cell proliferation and prognosis in these tumors. |
Product Type | Antibodies Primary |
Protocol | IHC: 1:20 |
Research Area | Clinical Diagnostic |
Size | 1 mL |
Source / Host | rabbit |
Species Reactivity | human |
Storage | 2-8ºC |
Substrate / Buffer | Antibody to Aurora B is affinity purified and diluted 10mM phosphate buffered saline (PBS), pH 7.2 containing 1% bovine serum albumin (BSA) and 0.09% sodium azide (NaN3). |
Product Page Updated | 2023-10-02T09:48:37.458Z |