Article No
AC-0242A
Application | IHC |
Article No | AC-0242A |
Country Availability | SE, FI, DK, NO, IS, FO, GL |
Clone | EP278 |
Clone Type | monoclonal |
Conjugation | Unconjugated |
Description | Bcl-6 |
Supplier | Cell Marque (Epitomics) |
Format | Concentrate |
Product Type | Antibodies Primary |
Protocol | Dilution Range: 1:20* |
Research Area | Clinical Diagnostic |
Size | 0.1 mL |
Source / Host | rabbit |
Species Reactivity | human |
Technical Specifications | Bcl-6 is a Kruppel-type zinc finger transcription factor spanning 706 amino acids. Bcl-6 plays a central role in germinal center (GC) formation, functioning as a regulator of B lymphocyte growth and development by protecting GC B cells from undergoing DNA damage-induced apotosis. Logarajah S et al. found that Bcl-6 is involved in mammary epithelial differentiation, which may play a potential role in carcinogenesis. Bcl-6 expression is mainly localized in GC B cells. Surrounding mantle- and marginal-zone B cells, as well as plasma cells and marrow B-cell precursors are negative for Bcl-6. Bcl-6 protein is commonly detected in GC neoplasms including follicular lymphomas, diffuse large B-cell lymphoma (DLBCL) and Burkitt's lymphomas. Bcl-6 is not restricted to B-cell lineage, a considerable number of anaplastic large cell lymphoma also had Bcl-6 expression, especially in ALK positive cases. |
Product Page Updated | 2023-10-02T09:48:37.458Z |