Article No
AFC-FY7N8J-0.1
Anti-Hu CD279 Purified
Anti-Hu CD279 Purified
Antibodies Primary
Specifications
| Application | FC, IHC |
| Article No | AFC-FY7N8J-0.1 |
| Biosite Brand | Biosite Flow |
| Country Availability | all |
| Clone | EH12.2H7 |
| Clone Type | monoclonal |
| Concentration | 1 mg/ml |
| Conjugation | Unconjugated |
| Description | Anti-Hu CD279 Purified |
| Supplier | Nordic Biosite |
| Entrez Gene ID | 5133 |
| Format | Purified |
| Immunogen | recombinant human CD279 |
| Isotype | IgG1 k |
| Keywords | CD and Related Antigens (Human) |
| Notes | CD279 / PD-1 (programmed cell death 1), a transmembrane protein of CD28/CTLA-4 family. It is expressed inducibly mainly on activated T, B, and myeloid cells and plays a role in maintaining peripheral self-tolerance. Binding to its ligands CD273 and CD274 is associated with inhibition of T cell proliferation and induction of their anergy. It is also expressed during thymic development. Some variants of CD279 are associated with susceptibility to systemic lupus erythematosus, type 1 diabetes, and rheumatoid arthritis. |
| Alias Names | PDCD1, PD1, SLEB2 |
| Previous Article No | AFC-27C56B, AFC-FY7N8J-0.1 |
| Product Type | Antibodies Primary |
| Protocol | Flow cytometry: Recommended dilution: 1-4 μg/ml. |
| Purification | Purified by protein-A affinity chromatography. |
| Purity | > 95% (by SDS-PAGE) |
| Size | 0.1 mg |
| Source / Host | mouse |
| Species Reactivity | monkey, human |
| Storage | Store at 2-8°C. Do not freeze. |
| Substrate / Buffer | Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide |
| Technical Specifications | The mouse monoclonal antibody EH12.2H7 recognizes an extracellular epitope of CD279 / PD-1 (programmed cell death 1), a 55 kDa type I transmembrane protein expressed above all during T cell development, on activated T cells, activated B cells, and activated monocytes. |
| UniProt Number | Q15116 |
| Product Page Updated | 2024-01-03T12:18:20.318Z |
