Article No
AFC-LQ26UX-0.1
Application | FC, IP, ELISA |
Article No | AFC-LQ26UX-0.1 |
Biosite Brand | Biosite Flow |
Country Availability | all |
Clone | 4B4-1 |
Clone Type | monoclonal |
Concentration | 1 mg/ml |
Conjugation | Unconjugated |
Description | Anti-Hu CD137 Purified |
Supplier | Nordic Biosite |
Entrez Gene ID | 3604 |
Format | Purified |
Immunogen | Recombinant human CD137 ectodomain |
Isotype | IgG1 k |
Keywords | CD and Related Antigens (Human) |
Notes | CD137, also known as TNFRSF9 or 4-1BB, is an inducible costimulatory molecule expressed mainly on activated T cells. Its ligand, known as 4-1BBL, is expressed on activated macrophages, mature B cells, hematopoietic stem cells, and myeloid progenitor cells. CD137 signaling leads to maintaining the survival of activated T cells and CD8+ memory T cells, and clonal expansion of T cells, but also to suppressing myelopoiesis and dendritic cell development. Triggered CD137 induces a cytokine release profile regulating peripheral monocyte survival. Soluble forms of CD137 may provide negative control mechanism for some immune responses. |
Alias Names | TNFRSF9, 41BB, 4-1BB, MGC2172 |
Previous Article No | AFC-4141-1, AFC-LQ26UX-0.1 |
Product Type | Antibodies Primary |
Protocol | Flow cytometry: Recommended dilution: 1-4 µg/ml |
Purification | Purified by protein-A affinity chromatography. |
Purity | > 95% (by SDS-PAGE) |
Research Area | Immunology |
Size | 0.1 mg |
Source / Host | mouse |
Species Reactivity | human, monkey |
Storage | Store at 2-8°C. Do not freeze. |
Substrate / Buffer | Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide |
Technical Specifications | The mouse monoclonal antibody 4B4-1 recognizes an extracellular conformational epitope on CD137, an approximately 40 kDa type I transmembrane protein of the TNFR family expressed mainly on activated T cells. |
UniProt Number | Q07011 |
Product Page Updated | 2024-01-03T12:18:20.318Z |