Article No
AFC-B7NLVD-0.1
Specifications
| Application | WB, ICC |
| Article No | AFC-B7NLVD-0.1 |
| Biosite Brand | Biosite Flow |
| Country Availability | all |
| Clone | DAXX-01 |
| Clone Type | monoclonal |
| Concentration | 1 mg/ml |
| Conjugation | Unconjugated |
| Description | Anti-DAXX Purified |
| Supplier | Nordic Biosite |
| Entrez Gene ID | 1616 |
| Format | Purified |
| Immunogen | Recombinant C-terminal part (aa 558-740) of human Daxx. |
| Isotype | IgG1 |
| Keywords | Transcription Regulation & Nuclear Proteins (Human), Apoptosis (Human), Transcription Regulation & Nuclear Proteins, Apoptosis |
| Notes | Daxx is an apoptosis-modulating death domain-associated protein with functions in transcriptional regulation. Daxx functions both in cytoplasm, where it interacts with Fas, and in nucleus (residing in PML oncogenic domains), where it is involved in SUMO-dependent regulation of transcription and subnuclear compartmentalization. Daxx senzitizes the cells to apoptosis, but on the other hand, this protein may also serve in preventing apoptosis in the early embryo. Even regarding the transcription, Daxx can serve both as a corepressor and a coactivator. During ischemic stress, Daxx translocates from the nucleus to the cytoplasm, where in regulates sodium hydrogen exchanger isoform 1 (NHE1). |
| Alias Names | DAP6, EAP1, BING2 |
| Previous Article No | AFC-4274-2, AFC-B7NLVD-0.1 |
| Product Type | Antibodies Primary |
| Purification | Purified by protein-A affinity chromatography. |
| Purity | > 95% (by SDS-PAGE) |
| Research area | Cell Proliferation |
| Size | 0.1 mg |
| Source / Host | mouse |
| Species Reactivity | human |
| Storage | Store at 2-8°C. Do not freeze. |
| Substrate / Buffer | Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide |
| Technical Specifications | The mouse monoclonal antibody DAXX-01 recognizes Daxx, a cytoplasmic death domain containing protein mainly expressed in fetal and adult human and mouse tissue. |
| UniProt Number | Q9UER7 |
| Product Page Updated | 2024-01-03T12:18:20.318Z |
