Article No
AFC-U84X6Z-0.1
Application | FC, IP, IHC |
Article No | AFC-U84X6Z-0.1 |
Biosite Brand | Biosite Flow |
Country Availability | all |
Clone | BU15 |
Clone Type | monoclonal |
Concentration | 1 mg/ml |
Conjugation | Unconjugated |
Description | Anti-Hu CD11c Purified |
Supplier | Nordic Biosite |
Entrez Gene ID | 3687 |
Format | Purified |
Immunogen | Dendritic cells of synovial fluid |
Isotype | IgG1 |
Keywords | CD Antigens & MHC (Veterinary), CD and Related Antigens (Human) |
Notes | CD11c (p150, alphaX integrin subunit) forms complex with CD18 (beta2 integrin subunit) and is expressed mainly on tissue macrophages and dendritic cells. CD11c binds to complement fragment iC3b, fibrinogen, VCAM-1 and ICAM-2 or e.g. CD90. Like other beta2 integrins, CD11c/CD18 plays roles in cell migration and phagocytosis. Moreover, interaction of CD11c/CD18 with plasminogen regulates plasmin activities, and interaction with heparin counteracts binding of iC3b. |
Alias Names | Integrin alpha X, ITGAX, SLEB6 |
Previous Article No | AFC-4418-2, AFC-U84X6Z-0.1 |
Product Type | Antibodies Primary |
Protocol | Flow cytometry: Recommended dilution: 1-4 μg/ml. |
Purification | Purified by protein-A affinity chromatography. |
Purity | > 95% (by SDS-PAGE) |
Research area | Immunology |
Size | 0.1 mg |
Source / Host | mouse |
Species Reactivity | human, monkey |
Storage | Store at 2-8°C. Do not freeze. |
Substrate / Buffer | Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide |
Technical Specifications | The antibody BU15 reacts with an extracellular epitope of CD11c (alphaX, p150), a 150 kDa integrin expressed mainly on dendritic cells and tissue macrophages. |
UniProt Number | P20702 |
Product Page Updated | 2024-01-03T12:18:20.318Z |