CD19 is a transmembrane glycoprotein of Ig superfamily expressed by B cells from the time of heavy chain rearrangement until plasma cell differentiation. It forms a tetrameric complex with CD21 (complement receptor type 2), CD81 (TAPA-1) and Leu13. Together with BCR (B cell antigen receptor), this complex signals to decrease B cell treshold for activation by the antigen. Besides being signal-amplifying coreceptor for BCR, CD19 can also signal independently of BCR coligation and it turns out to be a central regulatory component upon which multiple signaling pathways converge. Mutation of the CD19 gene results in hypogammaglobulinemia, whereas CD19 overexpression causes B cell hyperactivity.
Alias Names
B4, Leu-12, CVID3
Previous Article No
AFC-4515-2, AFC-7ONVJK-0.1
Product Type
Antibodies Primary
Protocol
Flow cytrometry: Recommended dilution: 1 μg/ml.
Purification
Purified by protein-A affinity chromatography.
Purity
> 95% (by SDS-PAGE)
Research area
Immunology
Size
0.1 mg
Source / Host
mouse
Species Reactivity
human
Storage
Store at 2-8°C. Do not freeze.
Substrate / Buffer
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Technical Specifications
The mouse monoclonal antibody 4G7 recognizes an extracellular epitope of human CD19.
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