Article No
AFC-UJHG5L-0.1
Anti-Hu CD1c Purified
Anti-Hu CD1c Purified
Antibodies Primary
Specifications
| Application | FC, IP, IHC |
| Article No | AFC-UJHG5L-0.1 |
| Biosite Brand | Biosite Flow |
| Country Availability | all |
| Clone | L161 |
| Clone Type | monoclonal |
| Concentration | 1 mg/ml |
| Conjugation | Unconjugated |
| Description | Anti-Hu CD1c Purified |
| Supplier | Nordic Biosite |
| Entrez Gene ID | 911 |
| Format | Purified |
| Immunogen | human thymocytes |
| Isotype | IgG1 k |
| Keywords | CD and Related Antigens (Human) |
| Notes | CD1c (also known as R7 or BDCA1) together with CD1a and b, belongs to group 1 of CD1 antigens. These non-classical MHC-like glycoproteins serve as antigen-presenting molecules for a subset of T cells that responds to specific lipids and glycolipids found in the cell walls of bacterial pathogens or self-glycolipid antigens such as gangliosides, and they have also roles in antiviral immunity. The trafficking routes of the particular CD1 types differ and correspond to their ability to bind and present different groups of antigens. CD1c is unique in its ability to present e.g. mycobacterial phosphoketides and polyisoprenoids. CD1c is the only CD1 isoform that has been shown to interact both with alpha/beta and gamma/delta T cells. |
| Alias Names | R7, BDCA1 |
| Previous Article No | AFC-4584-2, AFC-UJHG5L-0.1 |
| Product Type | Antibodies Primary |
| Protocol | Flow cytometry: Recommended dilution: 1-4 μg/ml. |
| Purification | Purified by protein-A affinity chromatography. |
| Purity | > 95% (by SDS-PAGE) |
| Research area | Immunology |
| Size | 0.1 mg |
| Source / Host | mouse |
| Species Reactivity | human |
| Storage | Store at 2-8°C. Do not freeze. |
| Substrate / Buffer | Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide |
| Technical Specifications | The mouse monoclonal antibody L161 recognizes an extracellular epitope of CD1c, (R7), a 43 kDa type I glycoprotein associated with beta2-microglobulin. It is expressed on cortical thymocytes (strongly), Langerhans cells, dendritic cells, B and some T cells. |
| UniProt Number | P29017 |
| Product Page Updated | 2024-01-03T12:18:20.318Z |
