Article No
AFC-AKEY46-0.1
Anti-Hu CD178 Purified
Anti-Hu CD178 Purified
Antibodies Primary
Specifications
| Application | FC, IP, WB, ICC |
| Article No | AFC-AKEY46-0.1 |
| Biosite Brand | Biosite Flow |
| Country Availability | all |
| Clone | NOK-1 |
| Clone Type | monoclonal |
| Concentration | 1 mg/ml |
| Conjugation | Unconjugated |
| Description | Anti-Hu CD178 Purified |
| Supplier | Nordic Biosite |
| Entrez Gene ID | 356 |
| Format | Purified |
| Immunogen | L5178Y mouse T lymphoma cells expressing recombinant human CD178 |
| Isotype | IgG1 |
| Keywords | Apoptosis (Human), CD and Related Antigens (Human) |
| Notes | CD178 / Fas-L (Fas ligand, CD95L), a member of TNF family transmembrane glycoproteins, is responsible for induction of apoptosis in cells containing its receptor CD95 / Fas. The CD178-mediated apoptosis pathway has been implicated in peripheral tolerance, tissue pathology, and maintenance of the immune privileged sites. Defects in this interaction may be related to some cases of systemic lupus erythematosus (SLE). CD178 was also described as a co-stimulatory receptor for T-cell activation in mice in vivo. |
| Alias Names | APTL, FASL, FAS-ligand, CD95L, TNFSF6, TNLG1A |
| Previous Article No | AFC-4586-2, AFC-AKEY46-0.1 |
| Product Type | Antibodies Primary |
| Protocol | Flow cytometry: Recommended dilution: 1-4 µg/ml |
| Purification | Purified by protein-A affinity chromatography. |
| Purity | > 95% (by SDS-PAGE) |
| Research area | Cell Death |
| Size | 0.1 mg |
| Source / Host | mouse |
| Species Reactivity | human |
| Storage | Store at 2-8°C. Do not freeze. |
| Substrate / Buffer | Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide |
| Technical Specifications | The mouse monoclonal antibody NOK-1 recognizes an extracellular epitope of CD178 / Fas-L, an approximately 40 kDa transmembrane glycoprotein expressed on neutrophils, monocytes, and activated T and NK cells. |
| UniProt Number | P48023 |
| Product Page Updated | 2024-01-03T12:18:20.318Z |
