Article No
AFC-IT63M4-0.1
Anti-Hu CD169 Purified
Anti-Hu CD169 Purified
Antibodies Primary
Specifications
| Application | FC, IP, WB, IHC |
| Article No | AFC-IT63M4-0.1 |
| Biosite Brand | Biosite Flow |
| Country Availability | all |
| Clone | 7-239 |
| Clone Type | monoclonal |
| Concentration | 1 mg/ml |
| Conjugation | Unconjugated |
| Description | Anti-Hu CD169 Purified |
| Supplier | Nordic Biosite |
| Entrez Gene ID | 6614 |
| Format | Purified |
| Immunogen | human rhinovirus 14-infected monocyte-derived dendritic cells |
| Isotype | IgG1 |
| Keywords | CD and Related Antigens (Human) |
| Notes | CD169, also known as Siglec-1 or sialoadhesin, is a type I transmembrane glycoprotein of the sialic acid binding Ig-like lectin family. It binds to sialylated glycoproteins on various haematopoietic cells to mediate cell-cell interactions. CD169 is expressed on a subset of macrophages and dendritic cells. On CD14+ monocytes its expression can be induced by interferon alpha and gamma. High expression of CD169 is observed in the spleen, lymph nodes, bone marrow, and under inflammatory conditions rheumatoid arthritis and atherosclerosis, lower in the liver, lungs and gut. It has been shown to be involved in antigen presentation to invariant NKT cells, which play an important role in the innate arm of the immune system to modulate the subsequent acquired immune responses. |
| Alias Names | SIGLEC1, SN, sialoadhesin |
| Previous Article No | AFC-4610-2, AFC-IT63M4-0.1 |
| Product Type | Antibodies Primary |
| Protocol | Flow cytometry: Recommended dilution: 1-4 µg/ml |
| Purification | Purified by protein-A affinity chromatography. |
| Purity | > 95% (by SDS-PAGE) |
| Research area | Immunology |
| Size | 0.1 mg |
| Source / Host | mouse |
| Species Reactivity | human |
| Storage | Store at 2-8°C. Do not freeze. |
| Substrate / Buffer | Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide |
| Technical Specifications | The mouse monoclonal antibody 7-239 recognizes an extracellular epitope of CD169 (sialoadhesin, Siglec-1), a 210 kDa type I transmembrane glycoprotein expressed on macrophages and dendritic cells. |
| UniProt Number | Q9BZZ2 |
| Product Page Updated | 2024-01-03T12:18:20.318Z |
