Article No
AFC-OPRC7O-100
Application | FC |
Article No | AFC-OPRC7O-100 |
Biosite Brand | Biosite Flow |
Country Availability | all |
Clone | BU15 |
Clone Type | monoclonal |
Conjugation | PErCP |
Description | Anti-Hu CD11c PerCP |
Recommended Dilution | The purified antibody is conjugated with Peridinin-chlorophyll-protein complex (PerCP) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. No reconstitution is necessary. |
Supplier | Nordic Biosite |
Entrez Gene ID | 3687 |
Format | PerCP |
Immunogen | Dendritic cells of synovial fluid |
Isotype | IgG1 |
Keywords | CD Antigens & MHC (Veterinary), CD and Related Antigens (Human) |
Notes | CD11c (p150, alphaX integrin subunit) forms complex with CD18 (beta2 integrin subunit) and is expressed mainly on tissue macrophages and dendritic cells. CD11c binds to complement fragment iC3b, fibrinogen, VCAM-1 and ICAM-2 or e.g. CD90. Like other beta2 integrins, CD11c/CD18 plays roles in cell migration and phagocytosis. Moreover, interaction of CD11c/CD18 with plasminogen regulates plasmin activities, and interaction with heparin counteracts binding of iC3b. |
Alias Names | Integrin alpha X, ITGAX, SLEB6 |
Previous Article No | AFC-5539-2 |
Product Type | Antibodies Primary |
Protocol | Flow cytometry: The reagent is designed for analysis of human blood cells using 10 μl reagent / 100 μl of whole blood or 106 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests. |
Purification | Purified antibody is conjugated with activated Peridinin-Chlorophyll Protein (PerCP) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography. |
Research area | Immunology |
Size | 100 tests |
Source / Host | mouse |
Species Reactivity | human, monkey |
Storage | Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze. |
Substrate / Buffer | Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide |
Technical Specifications | The antibody BU15 reacts with an extracellular epitope of CD11c (alphaX, p150), a 150 kDa integrin expressed mainly on dendritic cells and tissue macrophages. |
UniProt Number | P20702 |
Product Page Updated | 2024-01-03T12:18:20.318Z |