Article No
AFC-VYN4QL-0.1
Application | FC, IHC |
Article No | AFC-VYN4QL-0.1 |
Biosite Brand | Biosite Flow |
Country Availability | all |
Clone | OX-104 |
Clone Type | monoclonal |
Concentration | 1 mg/ml |
Conjugation | Unconjugated |
Description | Anti-Hu CD200 Purified |
Supplier | Nordic Biosite |
Entrez Gene ID | 4345 |
Format | Purified |
Immunogen | recombinant human CD200 |
Isotype | IgG1 k |
Keywords | Neurobiology (Human), CD and Related Antigens (Human) |
Notes | CD200 (also known as OX2 or MRC) is a type-1 membrane glycoprotein, which contains two extracellular immunoglobulin domains, transmembrane domain and cytoplasmic domain. It is expressed by neuronal cells, B and T cell subsets, follicular dendritic cells, keratinocytes, and ovarian cells. The interaction between CD200 and its receptor CD200R results in macrophage activation (IL-6 production), inhibition of mast cell degranulation along with reduced TNF-alpha and IL-13 secretion and overall attenuation of the activation status of lymphocytes. It seems CD200 is also involved in maternal tolerance and its decreased expression in hair follicle correlates with follicular miniaturization. |
Alias Names | MRC, MOX, OX-2 |
Previous Article No | AFC-764EA7, AFC-VYN4QL-0.1 |
Product Type | Antibodies Primary |
Protocol | Flow cytometry: Recommended dilution: 1-4 μg/ml. |
Purification | Purified by protein-A affinity chromatography. |
Purity | > 95% (by SDS-PAGE) |
Size | 0.1 mg |
Source / Host | mouse |
Species Reactivity | human |
Storage | Store at 2-8°C. Do not freeze. |
Substrate / Buffer | Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide |
Technical Specifications | The mouse monoclonal antibody OX-104 recognizes an extracellular epitope of CD200, a type-1 glycoprotein of the immunoglobulin superfamily, which is expressed in neurons, B and T cell subsets, keratinocytes, follicular dendritic cells, and ovarian cells. |
UniProt Number | P41217 |
Product Page Updated | 2024-01-03T12:18:20.318Z |