Article No
AFC-TMIYRB-100
Specifications
| Application | FC |
| Article No | AFC-TMIYRB-100 |
| Biosite Brand | Biosite Flow |
| Country Availability | all |
| Clone | 1A1 |
| Clone Type | monoclonal |
| Conjugation | PE |
| Description | Anti-Hu CD267 PE |
| Recommended Dilution | The purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. No reconstitution is necessary. |
| Supplier | Nordic Biosite |
| Entrez Gene ID | 23495 |
| Format | PE |
| Immunogen | CD267-transfected RBL cells |
| Isotype | IgG2a k |
| Keywords | CD and Related Antigens (Human) |
| Notes | CD267 / TACI (transmembrane activator calcium modulator and cyclophilin ligand interactor), a TNFR superfamily transmembrane protein, is expressed on B cells (predominantly on CD27+ memory cells), multiple myeloma cells and B cell chronic lymphocytic leukemia (B-CLL). Its triggering leads to activation of the transcription factors NFAT, AP1, and NF-kappa-B. It plays a crucial role in humoral immunity. Mutations in CD267 are associated with common variable immunodeficiency and IgA deficiency. |
| Alias Names | RYZN, TACI, CVID2, IGAD2, TNFRSF14B |
| Previous Article No | AFC-CE894F |
| Product Type | Antibodies Primary |
| Protocol | Flow cytometry: The reagent is designed for analysis of human blood cells using 10 μl reagent / 100 μl of whole blood or 106 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests. |
| Purification | Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography. |
| Size | 100 tests |
| Source / Host | mouse |
| Species Reactivity | human |
| Storage | Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze. |
| Substrate / Buffer | Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide |
| Technical Specifications | The rat monoclonal antibody 1A1 recognizes an extracellular epitope of CD267 / TACI, a 32 kDa type III transmembrane protein expressed by B cells and possibly by some activated T cells. |
| UniProt Number | O14836 |
| Product Page Updated | 2024-01-03T12:18:20.318Z |
