Article No
AG-20A-0043-C050
Application | ELISA, IP, WB |
Article No | AG-20A-0043-C050 |
Country Availability | SE, FI, DK, NO, IS, EE, LV, LT |
Clone | IL33026B |
Clone Type | monoclonal |
Concentration | 1 mg/ml |
Conjugation | Unconjugated |
Description | anti-IL-33, mAb (IL33026B) |
Supplier | Adipogen Life Sciences |
Entrez Gene ID | 90865 |
Format | Liquid |
Gene Symbol | IL33 |
Immunogen | Recombinant human IL-33. |
Isotype | IgG1 k |
Notes | Interleukin-33 (IL-33; HF-NEV; IL-1F11), a member of the IL-1 family of cytokines, is expressed by many cell types following pro-inflammatory stimulation and is thought to be released on cell lysis. The 30kDa human IL33 is converted by CASP1 to a 18kDa protein. IL33 binds to and signals through ST2 (IL1R1) and its stimulation recruits MYD88, IRAK, IRAK4, and TRAF6, followed by phosphorylation of ERK1(MAPK3)/ERK2(MAPK1), p38(MAPK14), and JNK. The ability of IL-33 to target numerous immune cell types, like Th2-like cells, mast cells, and B1 cells, and to induce cytokine and chemokine production underlines its potential in influencing the outcome of a wide range of diseases, such as arthritis, asthma, atopic allergy & anaphylaxis, cardiovascular disease/atherosclerosis, nervous system diseases, and sepsis.|Monoclonal Antibody. Recognizes human and mouse IL-33. Isotype: Mouse IgG1kappa. Clone: IL33026B. Applications: ELISA, IP, WB. Liquid. 0.2µm-filtered solution in PBS, pH 7.4. Contains no preservatives. Interleukin-33 (IL-33; HF-NEV; IL-1F11), a member of the IL-1 family of cytokines, is expressed by many cell types following pro-inflammatory stimulation and is thought to be released on cell lysis. The 30kDa human IL33 is converted by CASP1 to a 18kDa protein. IL33 binds to and signals through ST2 (IL1R1) and its stimulation recruits MYD88, IRAK, IRAK4, and TRAF6, followed by phosphorylation of ERK1(MAPK3)/ERK2(MAPK1), p38(MAPK14), and JNK. The ability of IL-33 to target numerous immune cell types, like Th2-like cells, mast cells, and B1 cells, and to induce cytokine and chemokine production underlines its potential in influencing the outcome of a wide range of diseases, such as arthritis, asthma, atopic allergy & anaphylaxis, cardiovascular disease/atherosclerosis, nervous system diseases, and sepsis. |
Alias Names | Interleukin-33; IL-1F11; NF-HEV |
Product Type | Antibodies Primary |
Research area | Inflammation |
Shipping Information | BLUE ICE |
Size | 50 ug |
Source / Host | mouse |
Species Reactivity | human, mouse |
Stability | Stable for at least 1 year after receipt when stored at -20°C. |
Storage | -20°C, 4°C |
Substrate / Buffer | Liquid. 0.2µm-filtered solution in PBS, pH 7.4. Contains no preservatives. |
Technical Specifications | Monoclonal Antibody. Recognizes human and mouse IL-33. Isotype: Mouse IgG1kappa. Clone: IL33026B. Applications: ELISA, IP, WB. Liquid. 0.2µm-filtered solution in PBS, pH 7.4. Contains no preservatives. Interleukin-33 (IL-33; HF-NEV; IL-1F11), a member of the IL-1 family of cytokines, is expressed by many cell types following pro-inflammatory stimulation and is thought to be released on cell lysis. The 30kDa human IL33 is converted by CASP1 to a 18kDa protein. IL33 binds to and signals through ST2 (IL1R1) and its stimulation recruits MYD88, IRAK, IRAK4, and TRAF6, followed by phosphorylation of ERK1(MAPK3)/ERK2(MAPK1), p38(MAPK14), and JNK. The ability of IL-33 to target numerous immune cell types, like Th2-like cells, mast cells, and B1 cells, and to induce cytokine and chemokine production underlines its potential in influencing the outcome of a wide range of diseases, such as arthritis, asthma, atopic allergy & anaphylaxis, cardiovascular disease/atherosclerosis, nervous system diseases, and sepsis. |
UniProt Number | O95760 |
Product Page Updated | 2024-02-01T08:25:01.492Z |