Article No
AG-20B-0014-C100
anti-NLRP3/NALP3, mAb (Cryo-2)
anti-NLRP3/NALP3, mAb (Cryo-2)
Antibodies Primary
Specifications
| Application | ChIP, ICC, IHC, IP, WB |
| Article No | AG-20B-0014-C100 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT |
| Clone | Cryo-2 |
| Clone Type | monoclonal |
| Concentration | 1 mg/ml |
| Conjugation | Unconjugated |
| Description | anti-NLRP3/NALP3, mAb (Cryo-2) |
| Supplier | Adipogen Life Sciences |
| Entrez Gene ID | 216799 |
| Format | Liquid |
| Gene Symbol | Nlrp3 |
| Immunogen | Recombinant mouse NLRP3/NALP3 (pyrin domain/aa 1-93). |
| Isotype | IgG2b |
| Notes | Monoclonal Antibody. Recognizes mouse and human NLRP3/NALP3. Isotype: Mouse IgG2b. Clone: Cryo-2. Applications: IHC, IP, WB. Liquid. In PBS containing 10% glycerol and 0.02% sodium azide. The inflammasome is a multiprotein complex that mediates the activation of caspase-1, which promotes, amongst others, the secretion of the proinflammatory cytokines interleukin (IL)-1beta and IL-18. Members of the Nod-like receptor family, including NLRP3/NALP3, are critical components of the inflammasome that link danger-signals to caspase-1 activation. Defects in NLRP3 are the cause of familial cold autoinflammatory syndrome type 1 (FCAS1), Muckle-Wells syndrome (MWS) and of chronic infantile neurologic cutaneous and articular syndrome (CINCA).|The inflammasome is a multiprotein complex that mediates the activation of caspase-1, which promotes, amongst others, the secretion of the proinflammatory cytokines interleukin (IL)-1beta and IL-18. Members of the Nod-like receptor family, including NLRP3/NALP3, are critical components of the inflammasome that link danger-signals to caspase-1 activation. Defects in NLRP3 are the cause of familial cold autoinflammatory syndrome type 1 (FCAS1), Muckle-Wells syndrome (MWS) and of chronic infantile neurologic cutaneous and articular syndrome (CINCA). |
| Alias Names | NACHT-, LRR- and PYD-containing Protein 3; NLRP3; Cryopyrin; Cold Autoinflammatory Syndrome 1 Protein |
| Product Type | Antibodies Primary |
| Protocol | Western Blot: 1μg/ml |
| Purity | >95% |
| Research area | Inflammation |
| Shipping Information | BLUE ICE |
| Size | 100 ug |
| Source / Host | mouse |
| Species Reactivity | human, mouse |
| Stability | Stable for at least 1 year after receipt when stored at -20°C. |
| Storage | -20°C, 4°C |
| Substrate / Buffer | Liquid. In PBS containing 10% glycerol and 0.02% sodium azide. |
| Technical Specifications | Monoclonal Antibody. Recognizes mouse and human NLRP3/NALP3. Isotype: Mouse IgG2b. Clone: Cryo-2. Applications: IHC, IP, WB. Liquid. In PBS containing 10% glycerol and 0.02% sodium azide. The inflammasome is a multiprotein complex that mediates the activation of caspase-1, which promotes, amongst others, the secretion of the proinflammatory cytokines interleukin (IL)-1beta and IL-18. Members of the Nod-like receptor family, including NLRP3/NALP3, are critical components of the inflammasome that link danger-signals to caspase-1 activation. Defects in NLRP3 are the cause of familial cold autoinflammatory syndrome type 1 (FCAS1), Muckle-Wells syndrome (MWS) and of chronic infantile neurologic cutaneous and articular syndrome (CINCA). |
| UniProt Number | Q8R4B8 |
| Product Page Updated | 2024-02-15T09:51:04.532Z |
