Article No
AG-20B-0036PF-C500
anti-CD40 (mouse), mAb (FGK45) (preservative free)
anti-CD40 (mouse), mAb (FGK45) (preservative free)
Antibodies Primary
Specifications
| Additional Information | Widely used stimulatory MAb to CD40. Shown to indirectly activate natural killer (NK) cells, producing significant antitumor and antimetastatic effects. Effective in boosting immune responses against infectious agents and can potentially be used to treat chronic autoimmune inflammatory processes. |
| Application | FA, FC |
| Article No | AG-20B-0036PF-C500 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT |
| Clone | FGK45 |
| Clone Type | monoclonal |
| Concentration | 1 mg/ml |
| Conjugation | Unconjugated |
| Description | anti-CD40 (mouse), mAb (FGK45) (preservative free) |
| Supplier | Adipogen Life Sciences |
| Endotoxin | <0.01EU/µg purified protein (LAL test; Lonza). |
| Entrez Gene ID | 21939 |
| Additional Information | Widely used stimulatory MAb to CD40. Shown to indirectly activate natural killer (NK) cells, producing significant antitumor and antimetastatic effects. Effective in boosting immune responses against infectious agents and can potentially be used to treat chronic autoimmune inflammatory processes. |
| Format | Liquid |
| Gene Symbol | Cd40 |
| Immunogen | Recombinant mouse CD40 fusion protein. |
| Isotype | IgG2a |
| Notes | CD40 belongs to the TNF-receptor superfamily and is essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. The interaction of CD40-CD40L is necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. CD40 is constitutively expressed by antigen presenting cells, including dendritic cells, B cells and macrophages. Consistent with its widespread expression on normal cells, CD40 is also expressed on a wide range of tumor cells, including non-Hodgkin's and Hodgkin's lymphomas, myeloma and some carcinomas including nasopharynx, bladder, cervix, kidney and ovary.|Monoclonal Antibody. Recognizes mouse CD40. Isotype: Rat IgG2a. Clone: FGK45. Applications: FACS, FUNC. Liquid. In PBS. CD40 belongs to the TNF-receptor superfamily and is essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. The interaction of CD40-CD40L is necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. CD40 is constitutively expressed by antigen presenting cells, including dendritic cells, B cells and macrophages. Consistent with its widespread expression on normal cells, CD40 is also expressed on a wide range of tumor cells, including non-Hodgkin's and Hodgkin's lymphomas, myeloma and some carcinomas including nasopharynx, bladder, cervix, kidney and ovary. |
| Alias Names | Tumor Necrosis Factor Receptor Superfamily Member 5; CD40L Receptor |
| Product Type | Antibodies Primary |
| Protocol | Widely used stimulatory MAb to CD40. Shown to indirectly activate natural killer (NK) cells, producing significant antitumor and antimetastatic effects. Effective in boosting immune responses against infectious agents and can potentially be used to treat chronic autoimmune inflammatory processes. |
| Purity | >95% |
| Research area | Immunology |
| Shipping Information | BLUE ICE |
| Size | 500 ug |
| Source / Host | rat |
| Species Reactivity | mouse |
| Stability | Stable for at least 1 year after receipt when stored at -20°C. |
| Storage | -20°C, 4°C |
| Substrate / Buffer | Liquid. In PBS. |
| Technical Specifications | Monoclonal Antibody. Recognizes mouse CD40. Isotype: Rat IgG2a. Clone: FGK45. Applications: FACS, FUNC. Liquid. In PBS. CD40 belongs to the TNF-receptor superfamily and is essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. The interaction of CD40-CD40L is necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. CD40 is constitutively expressed by antigen presenting cells, including dendritic cells, B cells and macrophages. Consistent with its widespread expression on normal cells, CD40 is also expressed on a wide range of tumor cells, including non-Hodgkin's and Hodgkin's lymphomas, myeloma and some carcinomas including nasopharynx, bladder, cervix, kidney and ovary. |
| UniProt Number | P27512 |
| Product Page Updated | 2024-02-01T08:25:01.492Z |
