Article No
AG-40B-0022-C010
BAFF, Soluble (mouse) (rec.)
BAFF, Soluble (mouse) (rec.)
Proteins & Peptides
Specifications
| MW | ~26kDa (SDS-PAGE) |
| Article No | AG-40B-0022-C010 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT |
| Concentration | 0.1 mg/ml |
| Description | BAFF, Soluble (mouse) (rec.) |
| Supplier | Adipogen Life Sciences |
| Endotoxin | <0.01EU/µg purified protein (LAL test; Lonza). |
| Entrez Gene ID | 24099 |
| Format | Powder |
| Gene Symbol | Tnfsf13b |
| Notes | BAFF is mainly produced by innate immune cells such as neutrophils, monocytes, macrophages, dendritic cells, follicular dendritic cells. T cells, activated B cells, some malignant B cells and also non-lymphoid cells like astrocytes, synoviocytes and epithelial cells can also produce BAFF. BAFF binds three distinct receptors (BAFF-R, TACI and BCMA) expressed predominantly on B cells, although activated T cells also express BAFF-R. BAFF is a master regulator of peripheral B cell survival, and together with IL-6, promotes Ig class-switching and plasma cell differentiation. Besides its major role in B cell biology, BAFF co-stimulates activated T cells. Deregulated expression of BAFF leads to autoimmune disorders in mice. In humans, elevated levels of soluble BAFF have been detected in the serum of patients with various autoimmune diseases such as Sjoegren syndrome, Rheumatoid arthritis (RA), Multiple sclerosis (MS) and Systemic Lupus Erythematosus (SLE). BAFF has also increased levels in some lymphoid cancers.|Protein. Mouse BAFF (aa 127-309) is fused at the N-terminus to a FLAG®-tag. Source: HEK 293 cells. Endotoxin content: 90% (SDS-PAGE). BAFF is mainly produced by innate immune cells such as neutrophils, monocytes, macrophages, dendritic cells, follicular dendritic cells. T cells, activated B cells, some malignant B cells and also non-lymphoid cells like astrocytes, synoviocytes and epithelial cells can also produce BAFF. BAFF binds three distinct receptors (BAFF-R, TACI and BCMA) expressed predominantly on B cells, although activated T cells also express BAFF-R. BAFF is a master regulator of peripheral B cell survival, and together with IL-6, promotes Ig class-switching and plasma cell differentiation. Besides its major role in B cell biology, BAFF co-stimulates activated T cells. Deregulated expression of BAFF leads to autoimmune disorders in mice. In humans, elevated levels of soluble BAFF have been detected in the serum of patients with various autoimmune diseases such as Sjoegren syndrome, Rheumatoid arthritis (RA), Multiple sclerosis (MS) and Systemic Lupus Erythematosus (SLE). BAFF has also increased levels in some lymphoid cancers. |
| Alias Names | Tumor Necrosis Factor Ligand Superfamily Member 13B; TNFSF13B; B Cell Activating Factor; CD257 |
| Product Type | Proteins & Peptides |
| Purity | >90% |
| Research area | Immunology |
| Sequence | Mouse BAFF (aa 127-309) is fused at the N-terminus to a FLAG®-tag. |
| Shipping Information | BLUE ICE |
| Size | 10 ug |
| Source / Host | mouse |
| Species Reactivity | human, mouse |
| Stability | Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C. |
| Storage | -20°C, 4°C |
| Substrate / Buffer | Lyophilized. Contains PBS. |
| Technical Specifications | Protein. Mouse BAFF (aa 127-309) is fused at the N-terminus to a FLAG®-tag. Source: HEK 293 cells. Endotoxin content: 90% (SDS-PAGE). BAFF is mainly produced by innate immune cells such as neutrophils, monocytes, macrophages, dendritic cells, follicular dendritic cells. T cells, activated B cells, some malignant B cells and also non-lymphoid cells like astrocytes, synoviocytes and epithelial cells can also produce BAFF. BAFF binds three distinct receptors (BAFF-R, TACI and BCMA) expressed predominantly on B cells, although activated T cells also express BAFF-R. BAFF is a master regulator of peripheral B cell survival, and together with IL-6, promotes Ig class-switching and plasma cell differentiation. Besides its major role in B cell biology, BAFF co-stimulates activated T cells. Deregulated expression of BAFF leads to autoimmune disorders in mice. In humans, elevated levels of soluble BAFF have been detected in the serum of patients with various autoimmune diseases such as Sjoegren syndrome, Rheumatoid arthritis (RA), Multiple sclerosis (MS) and Systemic Lupus Erythematosus (SLE). BAFF has also increased levels in some lymphoid cancers. |
| UniProt Number | Q9WU72 |
| Product Page Updated | 2024-02-01T08:25:01.492Z |
