Article No
AG-40T-0019-C002
TIP60 (human) (rec.) (His) (highly active)
TIP60 (human) (rec.) (His) (highly active)
Proteins & Peptides
Specifications
| Article No | AG-40T-0019-C002 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT |
| Concentration | Lot dependent (0.2-0.5mg/ml) |
| Description | TIP60 (human) (rec.) (His) (highly active) |
| Supplier | Adipogen Life Sciences |
| Entrez Gene ID | 10524 |
| Format | Liquid |
| Gene Symbol | KAT5 |
| Notes | Protein. Human TIP60 is fused to a His-tag. Source: Sf21 cells. Liquid. In 50mM TRIS-HCl, pH 7.5, containing 100mM sodium chloride, 0.2% NP-40, 50mM imidazole and 10% glycerol. Purity: >95% (SDS-PAGE). TIP60 is the catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex is required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. TIP60 directly acetylates and activates ataxia-telangiectasia mutated (ATM). In case of HIV-1 infection, interaction with the viral Tat protein leads to KAT5 polyubiquitination and targets it to degradation.|TIP60 is the catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex is required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. TIP60 directly acetylates and activates ataxia-telangiectasia mutated (ATM). In case of HIV-1 infection, interaction with the viral Tat protein leads to KAT5 polyubiquitination and targets it to degradation. |
| Alias Names | Histone Acetyltransferase HTATIP; Histone Acetyltransferase KAT5; Lysine Acetyltransferase 5; 60 kDa Tat-interactive Protein |
| Product Type | Proteins & Peptides |
| Purity | >95% |
| Research area | Metabolism |
| Sequence | Human TIP60 is fused to a His-tag. |
| Shipping Information | DRY ICE |
| Size | 2 ug |
| Source / Host | human |
| Species Reactivity | human |
| Stability | Stable for at least 6 months after receipt when stored at -80°C. |
| Storage | -20°C, -80°C |
| Substrate / Buffer | Liquid. In 50mM TRIS-HCl, pH 7.5, containing 100mM sodium chloride, 0.2% NP-40, 50mM imidazole and 10% glycerol. |
| Technical Specifications | Protein. Human TIP60 is fused to a His-tag. Source: Sf21 cells. Liquid. In 50mM TRIS-HCl, pH 7.5, containing 100mM sodium chloride, 0.2% NP-40, 50mM imidazole and 10% glycerol. Purity: >95% (SDS-PAGE). TIP60 is the catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex is required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. TIP60 directly acetylates and activates ataxia-telangiectasia mutated (ATM). In case of HIV-1 infection, interaction with the viral Tat protein leads to KAT5 polyubiquitination and targets it to degradation. |
| UniProt Number | Q92993 |
| Product Page Updated | 2024-02-01T08:25:01.492Z |
