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Bilobalide

Chemicals & Biochemicals

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Article No

AG-CN2-0026-M050

Size

50 mg

Shipping Information

Article No

AG-CN2-0026-M050

Size

50 mg

Specifications

CAS No	33570-04-6
MW	326.3
Article No	AG-CN2-0026-M050
Country Availability	SE, FI, DK, NO, IS, EE, LV, LT
Description	Bilobalide
Supplier	Adipogen Life Sciences
Format	Powder
Notes	Chemical. CAS: 33570-04-6. Formula: C15H18O8. MW: 326.3. Isolated from Ginko biloba. Neuroprotective. Mitochondrial gene expression regulator. ROS scavenger. Competitive GABA(A) receptor antagonist. Apoptosis inhibitor. CREB phosphorylation enhancer. Stimulates neurogenesis and synaptogenesis. Hepatic cytochrome P450 inducer. Activates the phosphatidylinositol 3-kinase (PI3K) dependent pathway. Potent anti-inflammatory and antihyperalgesic agent.\|Neuroprotective [2, 3, 4, 5, 7]. Mitochondrial gene expression regulator [3]. ROS scavenger [4]. Competitive GABA(A) receptor antagonist [6]. Apoptosis inhibitor [4, 7, 10, 11]. CREB phosphorylation enhancer. Stimulates neurogenesis and synaptogenesis [8]. Hepatic cytochrome P450 inducer [9]. Activates the phosphatidylinositol 3-kinase (PI3K) dependent pathway [10, 11]. Potent anti-inflammatory and antihyperalgesic agent [12].
Molecular Formula	C15H18O8
Product Type	Chemicals & Biochemicals
Purity	>95%
Research area	Cell Death
Shipping Information	RT
Size	50 mg
Solubility	Soluble in ethanol or DMSO.
Stability	Stable for at least 2 years after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
Storage	-20°C, 4°C
Technical Specifications	Chemical. CAS: 33570-04-6. Formula: C15H18O8. MW: 326.3. Isolated from Ginko biloba. Neuroprotective. Mitochondrial gene expression regulator. ROS scavenger. Competitive GABA(A) receptor antagonist. Apoptosis inhibitor. CREB phosphorylation enhancer. Stimulates neurogenesis and synaptogenesis. Hepatic cytochrome P450 inducer. Activates the phosphatidylinositol 3-kinase (PI3K) dependent pathway. Potent anti-inflammatory and antihyperalgesic agent.
Product Page Updated	2024-02-01T08:25:01.492Z

Documentation

Datasheet

MSDS

References

Bilobalid A, ein neues Sesquiterpen mit tert.-Butyl-Gruppe aus den Blättern von Ginkgo biloba L.: K. Weinges & W. Bähr; Liebigs Ann. Chem. 724, 214 (1969) | Protection of hypoxia-induced ATP decrease in endothelial cells by ginkgo biloba extract and bilobalide: D. Janssens, et al.; Biochem. Pharmacol. 50, 991 (1995) | Protection of mitochondrial respiration activity by bilobalide: D. Janssens, et al.; Biochem. Pharmacol. 58, 109 (1999) | Reactive oxygen species-induced apoptosis in PC12 cells and protective effect of bilobalide: L.J. Zhou & X.Z. Zhu; J. Pharmacol. Exp. Ther. 293, 982 (2000) | Bilobalide and neuroprotection: F.V. Defeudis; Pharmacol. Res. 46, 565 (2002) (Review) | Bilobalide, a sesquiterpene trilactone from Ginkgo biloba, is an antagonist at recombinant alpha1beta2gamma2L GABA(A) receptors: S.H. Huang, et al.; Eur. J. Pharmacol. 464, 1 (2003) | Neuroprotective effects of bilobalide, a component of Ginkgo biloba extract (EGb 761) in global brain ischemia and in excitotoxicity-induced neuronal death: K. Chandrasekaran, et al.; Pharmacopsychiatry 36 Suppl 1, S89 (2003) | Stimulation of neurogenesis and synaptogenesis by bilobalide and quercetin via common final pathway in hippocampal neurons: F. Tchantchou, et al.; J. Alzheimers Dis. 18, 787 (2009) | Time-dependent induction of hepatic cytochrome P450 enzyme activity and mRNA expression by bilobalide in rats: Y. Taki, et al.; J. Pharmacol. Sci. 109, 459 (2009) | Bilobalide prevents apoptosis through activation of the PI3K/Akt pathway in SH-SY5Y cells: C. Shi, et al.; Apoptosis 15, 715 (2010) | Bilobalide regulates soluble amyloid precursor protein release via phosphatidyl inositol 3 kinase-dependent pathway: C. Shi, et al.; Neurochem. Int. 59, 59 (2011) | Bilobalide, a unique constituent of Ginkgo biloba, inhibits inflammatory pain in rats: M. Goldie & S. Dolan; Behav. Pharmacol. 24, 298 (2013)

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