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Asiaticoside

Chemicals & Biochemicals

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Article No

AG-CN2-0080-M010

Size

10 mg

Shipping Information

Article No

AG-CN2-0080-M010

Size

10 mg

Specifications

CAS No	16830-15-2
MW	959.1
Article No	AG-CN2-0080-M010
Country Availability	SE, FI, DK, NO, IS, EE, LV, LT
Description	Asiaticoside
Supplier	Adipogen Life Sciences
Format	Powder
Notes	Antibacterial. Human collagen I synthesis inducer. Anti-wrinkle activity. Shows wound healing activity. Enhances normal human skin cell migration, attachment and growth. Suppresses collagen expression and TGF-beta/Smad signaling by inducing Smad7 and inhibiting TGF-betaRI and TGF-betaRII. Anti-inflammatory and antioxidant agent with anti-gastric ulcer activity. Mitogen-activated protein kinases (MAPKs), nuclear factor-kappaB (NF-kappaB), cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS; NOSII) expression, production of serum tumor necrosis factor (TNF-alpha) and interleukin-6 (IL-6) inhibitor. Anticancer agent. Shown to induce apoptosis and autophagy in cancer cells. Enhances antitumor activity of vincristine in cancer cells. Might be useful in cancer chemotherapy. Anxiolytic. Antidepressant-like activity. Hepatoprotective effects. CYP2C19 and CYP3A4 inhibitor. Neuroprotective. Antileishmanial activity. cPLA2 and sPLA2 inhibitor.\|Chemical. CAS: 16830-15-2. Formula: C48H78O19. MW: 959.1. Isolated from Centella asiatica. Antibacterial. Human collagen I synthesis inducer. Anti-wrinkle activity. Shows wound healing activity. Enhances normal human skin cell migration, attachment and growth. Suppresses collagen expression and TGF-beta/Smad signaling by inducing Smad7 and inhibiting TGF-betaRI and TGF-betaRII. Anti-inflammatory. Anti-gastric ulcer. Mitogen-activated protein kinases (MAPKs), nuclear factor-kappaB (NF-kappaB), cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS; NOSII) expression, production of serum tumor necrosis factor (TNF-alpha) and interleukin-6 (IL-6) inhibitor. Apoptosis inducer in cancer cells. Enhances antitumor activity of vincristine in cancer cells. Might be useful in cancer chemotherapy. Anxiolytic. Antidepressant-like activity. Hepatoprotective effects. CYP2C19 and CYP3A4 inhibitor. Neuroprotective. Antileishmanial activity. cPLA2 and sPLA2 inhibitor.
Molecular Formula	C48H78O19
Alias Names	Blastostimulina; Centelase; Emdecassol; Madecassol; Marticassol; FK1080; BRN 0078195; NSC 166062
Product Type	Chemicals & Biochemicals
Purity	>95%
Research area	Cell Death
Shipping Information	RT
Size	10 mg
Solubility	Soluble in ethanol, methanol or pyridine. Insoluble in water.
Stability	Stable for at least 2 years after receipt when stored at +4°C.
Storage	4°C
Technical Specifications	Chemical. CAS: 16830-15-2. Formula: C48H78O19. MW: 959.1. Isolated from Centella asiatica. Antibacterial. Human collagen I synthesis inducer. Anti-wrinkle activity. Shows wound healing activity. Enhances normal human skin cell migration, attachment and growth. Suppresses collagen expression and TGF-beta/Smad signaling by inducing Smad7 and inhibiting TGF-betaRI and TGF-betaRII. Anti-inflammatory. Anti-gastric ulcer. Mitogen-activated protein kinases (MAPKs), nuclear factor-kappaB (NF-kappaB), cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS; NOSII) expression, production of serum tumor necrosis factor (TNF-alpha) and interleukin-6 (IL-6) inhibitor. Apoptosis inducer in cancer cells. Enhances antitumor activity of vincristine in cancer cells. Might be useful in cancer chemotherapy. Anxiolytic. Antidepressant-like activity. Hepatoprotective effects. CYP2C19 and CYP3A4 inhibitor. Neuroprotective. Antileishmanial activity. cPLA2 and sPLA2 inhibitor.
Product Page Updated	2024-02-01T08:25:01.492Z

Documentation

Datasheet

MSDS

References

In vitro and in vivo wound healing activity of asiaticoside isolated from Centella asiatica: A. Shukla, et al.; J. Ethnopharmacol. 65, 1 (1999) | In vitro keratinocyte antiproliferant effect of Centella asiatica extract and triterpenoid saponins: J.H. Sampson, et al.; Phytomedicine 8, 230 (2001) | The healing effects of Centella extract and asiaticoside on acetic acid induced gastric ulcers in rats: C.L. Cheng, et al.; Life Sci. 74, 2237 (2004) | Inhibitory effects of Centella asiatica water extract and asiaticoside on inducible nitric oxide synthase during gastric ulcer healing in rats: J.S. Guo, et al.; Planta Med. 70, 1150 (2004) | Improving lip wrinkles: lipstick-related image analysis: J.S. Ryu, et al.; Skin Res. Technol. 11, 157 (2005) | Asiaticoside induces human collagen I synthesis through TGFbeta receptor I kinase (TbetaRI kinase)-independent Smad signaling: J. Lee, et al.; Planta Med. 72, 324 (2006) | Anxiolytic-like effect of asiaticoside in mice: S.W. Chen, et al.; Pharmacol. Biochem. Behav. 85, 339 (2006) | Effects of asiaticoside on the expression of Smad protein by normal skin fibroblasts and hypertrophic scar fibroblasts: S.H. Qi, et al.; Clin. Exp. Dermatol. 33, 171 (2008) | Antidepressant-like effect of asiaticoside in mice: X. Liang, et al.; Pharmacol. Biochem. Behav. 89, 444 (2008) | Protective effects of Asiaticoside on acute liver injury induced by lipopolysaccharide/D-galactosamine in mice: L. Zhang, et al.; Phytomedicine 17, 811 (2010) | Asiaticoside suppresses collagen expression and TGF-beta/Smad signaling through inducing Smad7 and inhibiting TGF-betaRI and TGF-betaRII in keloid fibroblasts: B. Tang, et al.; Arch. Dermatol. Res. 303, 563 (2011) | In vitro inhibitory effects of asiaticoside and madecassoside on human cytochrome P450: T. Winitthana, et al.; Toxicol. In Vitro 25, 890 (2011) | Asiaticoside: attenuation of neurotoxicity induced by MPTP in a rat model of Parkinsonism via maintaining redox balance and up-regulating the ratio of Bcl-2/Bax: C.L. Xu, et al.; Pharmacol. Biochem. Behav. 100, 413 (2012) | Asiaticoside induces tumour-necrosis-factor-alpha-mediated nitric oxide production to cure experimental visceral leishmaniasis caused by antimony-susceptible and -resistant Leishmania donovani strains: S.K. Bhaumik, et al.; J. Antimicrob. Chemother. 67, 910 (2012) | Inhibition of cPLA2 and sPLA2 activities in primary cultures of rat cortical neurons by Centella asiatica water extract: P.P. Defillipo, et al.; Nat. Prod. Commun. 7, 841 (2012) | Asiaticoside enhances normal human skin cell migration, attachment and growth in vitro wound healing model: J.H. Lee, et al.; Phytomedicine 19, 1223 (2012) | Antipyretic and Anti-inflammatory Effects of Asiaticoside in Lipopolysaccharide-treated Rat through Up-regulation of Heme Oxygenase-1: J. Wan, et al.; Phytother. Res. 27, 1136 (2013)

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