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Pyripyropene A

Chemicals & Biochemicals

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Article No

AG-CN2-0106-M001

Size

1 mg

Shipping Information

Article No

AG-CN2-0106-M001

Size

1 mg

Specifications

CAS No	147444-03-9
MW	583.6
Article No	AG-CN2-0106-M001
Country Availability	SE, FI, DK, NO, IS, EE, LV, LT
Description	Pyripyropene A
Supplier	Adipogen Life Sciences
Format	Powder
Notes	Antibiotic [1]. Highly specific inhibitor of acyl-coenzyme A:cholesterol acetyltransferase 2 (ACAT2) [1-6, 8, 9]. Anti-angiogenic [10]. Antiatherogenic and antiatherosclerotic agent. Shows cholesterol-lowering and atheroprotective activities. [7, 11, 12].\|Chemical. CAS: 147444-03-9. Formula: C31H37NO10. MW: 583.6. Isolated from Aspergillus fumigatus FO-1289. Antibiotic. Highly specific inhibitor of acyl-coenzyme A:cholesterol acetyltransferase 2 (ACAT2). Anti-angiogenic. Antiatherogenic and antiatherosclerotic agent. Shows cholesterol-lowering and atheroprotective activities.
Molecular Formula	C31H37NO10
Alias Names	(+)-Pyripyropene A; PPPA; FO 1289A
Product Type	Chemicals & Biochemicals
Purity	>95%
Research area	Metabolism
Shipping Information	RT
Size	1 mg
Solubility	Soluble in methanol, chloroform, ethyl acetate or DMSO. Insoluble in water or hexane.
Stability	Stable for at least 3 years after receipt when stored at -20°C.
Storage	-20°C, 4°C
Technical Specifications	Chemical. CAS: 147444-03-9. Formula: C31H37NO10. MW: 583.6. Isolated from Aspergillus fumigatus FO-1289. Antibiotic. Highly specific inhibitor of acyl-coenzyme A:cholesterol acetyltransferase 2 (ACAT2). Anti-angiogenic. Antiatherogenic and antiatherosclerotic agent. Shows cholesterol-lowering and atheroprotective activities.
Product Page Updated	2024-02-01T08:25:01.492Z

Documentation

Datasheet

MSDS

References

Pyripyropenes, highly potent inhibitors of acyl-CoA:cholesterol acyltransferase produced by Aspergillus fumigatus: S. Omura, et al.; J. Antibiot. (Tokyo) 46, 1168 (1993) | Pyripyropenes, novel inhibitors of acyl-CoA:cholesterol acyltransferase produced by Aspergillus fumigatus. II. Structure elucidation of pyripyropenes A, B, C and D: Y.K. Kim, et al.; J. Antibiot. (Tokyo) 47, 154 (1994) | Pyripyropenes, novel inhibitors of acyl-CoA:cholesterol acyltransferase produced by Aspergillus fumigatus. I. Production, isolation, and biological properties: H. Tomoda, et al.; J. Antibiot. (Tokyo) 47, 148 (1994) | Mass-production of human ACAT-1 and ACAT-2 to screen isoform-specific inhibitor: a different substrate specificity and inhibitory regulation: K.H. Cho, et al.; BBRC 309, 864 (2003) | Identification of ACAT1- and ACAT2-specific inhibitors using a novel, cell-based fluorescence assay: individual ACAT uniqueness: A.T. Lada, et al.; J. Lipid Res. 45, 378 (2004) | Selectivity of microbial acyl-CoA: cholesterol acyltransferase inhibitors toward isozymes: T. Ohshiro, et al.; J. Antibiot. (Tokyo) 60, 43 (2007) | Potential therapeutics for obesity and atherosclerosis: inhibitors of neutral lipid metabolism from microorganisms: H. Tomoda & S. Omura; Pharmacol. Ther. 115, 375 (2007) (Review) | Identification of the interaction site within acyl-CoA:cholesterol acyltransferase 2 for the isoform-specific inhibitor pyripyropene A: A. Das, et al.; J. Biol. Chem. 283, 10453 (2008) | Selectivity of pyripyropene derivatives in inhibition toward acyl-CoA:cholesterol acyltransferase 2 isozyme: T. Ohshiro, et al.; J. Antibiot. (Tokyo). 61, 503 (2008) | Pyripyropenes, fungal sesquiterpenes conjugated with alpha-pyrone and pyridine moieties, exhibits anti-angiogenic activity against human umbilical vein endothelial cells: A. Hayashi, et al.; Biol. Pharm. Bull. 32, 1261 (2009) | Pyripyropene A, an acyl-coenzyme A:cholesterol acyltransferase 2-selective inhibitor, attenuates hypercholesterolemia and atherosclerosis in murine models of hyperlipidemia: T. Ohshiro, et al.; Arterioscler. Thromb. Vasc. Biol. 31, 1108 (2011) | Isoform-specific inhibitors of ACATs: recent advances and promising developments: T. Ohshiro & H. Tomoda; Future Med. Chem. 3, 2039 (2011) (Review)

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