Article No
AG-CN2-0427-M250
Specifications
| CAS No | 446-72-0 |
| MW | 270.2 |
| Article No | AG-CN2-0427-M250 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT |
| Description | Genistein |
| Supplier | Adipogen Life Sciences |
| Format | Powder |
| Notes | Cell-permeable, reversible, substrate competitive tyrosine kinase inhibitor (including EGFR phosphorylation), implicated in almost all cell growth and proliferation signal cascades [1]. Inhibitor of mammalian DNA topoisomerase II [2]. Anticancer agent, inducing cell cycle arrest and apoptosis [3]. Antiangiogenic agent, down-regulates the transcription of genes involved in controlling angiogenesis [12]. Binds estrogen receptor beta. Can increase the rate of growth of some ER expressing breast cancers [4, 10]. Potent alpha-glucosidase inhibitor [5]. Anthelmintic [6]. Anti-diabetic. Activates nuclear receptors, oestrogen receptors and peroxisome proliferator-activated receptors (all PPAR isoforms) and it inhibits various enzyme activities [7, 8, 14]. Inhibitor of GLUT4-mediated glucose uptake in 3T3-L1 adipocytes [9]. Stimulator of autophagy vacuolization [12]. Antioxidant [13]. TRAIL sensitizer [15]. Acts as an agonist at the GPR30 receptor [16]. MALT1 inhibitor [17] DNA methyltransferase inhibitor [18]. Genistein exhibits synergistic antibacterial effects on MRSA [19].|Chemical. CAS: 446-72-0. Formula: C15H10O5. MW: 270.2. Synthetic. Cell-permeable, reversible, substrate competitive tyrosine kinase inhibitor (including EGFR phosphorylation), implicated in almost all cell growth and proliferation signal cascades. Inhibitor of mammalian DNA topoisomerase II. Anticancer agent, inducing cell cycle arrest and apoptosis. Antiangiogenic agent, down-regulates the transcription of genes involved in controlling angiogenesis. Binds estrogen receptor beta. Can increase the rate of growth of some ER expressing breast cancers. Potent alpha-glucosidase inhibitor. Anthelmintic. Anti-diabetic. Activates nuclear receptors, oestrogen receptors and peroxisome proliferator-activated receptors (all PPAR isoforms) and it inhibits various enzyme activities. Inhibitor of GLUT4-mediated glucose uptake in 3T3-L1 adipocytes. Stimulator of autophagy vacuolization. Antioxidant. TRAIL sensitizer. Acts as an agonist at the GPR30 receptor. MALT1 inhibitor DNA methyltransferase inhibitor. Genistein exhibits synergistic antibacterial effects on MRSA. |
| Molecular Formula | C15H10O5 |
| Alias Names | NSC 36586; Baichanin A; Differenol A; 4',5,7-Trihydroxyisoflavone; 5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one |
| Product Type | Chemicals & Biochemicals |
| Purity | >99% |
| Research area | Metabolism |
| Shipping Information | RT |
| Size | 250 mg |
| Solubility | Soluble in DMSO; slightly soluble in ethanol. Insoluble in water. |
| Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Storage | -20°C, 4°C |
| Technical Specifications | Chemical. CAS: 446-72-0. Formula: C15H10O5. MW: 270.2. Synthetic. Cell-permeable, reversible, substrate competitive tyrosine kinase inhibitor (including EGFR phosphorylation), implicated in almost all cell growth and proliferation signal cascades. Inhibitor of mammalian DNA topoisomerase II. Anticancer agent, inducing cell cycle arrest and apoptosis. Antiangiogenic agent, down-regulates the transcription of genes involved in controlling angiogenesis. Binds estrogen receptor beta. Can increase the rate of growth of some ER expressing breast cancers. Potent alpha-glucosidase inhibitor. Anthelmintic. Anti-diabetic. Activates nuclear receptors, oestrogen receptors and peroxisome proliferator-activated receptors (all PPAR isoforms) and it inhibits various enzyme activities. Inhibitor of GLUT4-mediated glucose uptake in 3T3-L1 adipocytes. Stimulator of autophagy vacuolization. Antioxidant. TRAIL sensitizer. Acts as an agonist at the GPR30 receptor. MALT1 inhibitor DNA methyltransferase inhibitor. Genistein exhibits synergistic antibacterial effects on MRSA. |
| Product Page Updated | 2024-02-01T08:25:01.492Z |
