Article No
AG-CN2-0512-G001
Colistin sulfate (Ph.Eur. Grade)
Colistin sulfate (Ph.Eur. Grade)
Chemicals & Biochemicals
Specifications
| CAS No | 1264-72-8 |
| MW | 2801.7 |
| Article No | AG-CN2-0512-G001 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT |
| Description | Colistin sulfate (Ph.Eur. Grade) |
| Supplier | Adipogen Life Sciences |
| Format | Powder |
| Notes | Chemical. CAS: 1264-72-8. Formula: 2(C52H98N16O13) . 5(H2SO4) (unspec.). MW: 2801.7. Isolated from Bacillus polymyxa. Very potent polymyxin antibiotic. Has only one amino acid difference compared to polymyxin B. Antimicrobial. Targets the lipopolysaccharide (LPS) of the outer membrane of Gram-negative bacteria. Competitively displaces divalent cations (Ca2+ and Mg2+) from the negatively-charged phosphate groups LPS, causing disruption of the membrane. This increases the permeability of the cell envelope, leakage of cell contents, leading to apoptosis and cell death. Used against multidrug-resistant Gram-negative bacterial infections.|Very potent polymyxin antibiotic. Has only one amino acid difference compared to polymyxin B. Antimicrobial. Targets the lipopolysaccharide (LPS) of the outer membrane of Gram-negative bacteria. Competitively displaces divalent cations (Ca2+ and Mg2+) from the negatively-charged phosphate groups LPS, causing disruption of the membrane. This increases the permeability of the cell envelope, leakage of cell contents, leading to apoptosis and cell death. Used against multidrug-resistant Gram-negative bacterial infections. |
| Molecular Formula | 2(C52H98N16O13) . 5(H2SO4) (unspec.) |
| Alias Names | Polymyxin E; Belcomycin; Colimycin |
| Product Type | Chemicals & Biochemicals |
| Purity | >77% |
| Research area | Microbiology |
| Shipping Information | RT |
| Size | 1 g |
| Solubility | Soluble in water (50mg/ml). |
| Stability | Stable for at least 2 years after receipt when stored at +4°C. |
| Storage | 4°C |
| Technical Specifications | Chemical. CAS: 1264-72-8. Formula: 2(C52H98N16O13) . 5(H2SO4) (unspec.). MW: 2801.7. Isolated from Bacillus polymyxa. Very potent polymyxin antibiotic. Has only one amino acid difference compared to polymyxin B. Antimicrobial. Targets the lipopolysaccharide (LPS) of the outer membrane of Gram-negative bacteria. Competitively displaces divalent cations (Ca2+ and Mg2+) from the negatively-charged phosphate groups LPS, causing disruption of the membrane. This increases the permeability of the cell envelope, leakage of cell contents, leading to apoptosis and cell death. Used against multidrug-resistant Gram-negative bacterial infections. |
| Product Page Updated | 2024-02-01T08:25:01.492Z |
