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Oligomycin A

Chemicals & Biochemicals

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Article No

AG-CN2-0517-M001

Size

1 mg

Shipping Information

Article No

AG-CN2-0517-M001

Size

1 mg

Specifications

CAS No	579-13-5
MW	791.1
Article No	AG-CN2-0517-M001
Country Availability	SE, FI, DK, NO, IS, EE, LV, LT
Description	Oligomycin A
Supplier	Adipogen Life Sciences
Format	Powder
Notes	Chemical. CAS: 579-13-5. Formula: C45H74O11. MW: 791.1. Synthetic. Originally isolated from Streptomyces diastatochromogenes. Potent mitochondrial ATP synthase (ATPases (F1F0)) inhibitor, consequently leading to inhibition of oxidative phosphorylation (OXPHOS). Useful agent for immunometabolism research. Inhibits ATP synthase by blocking its proton channel (F0 subunit), which is necessary for oxidative phosphorylation of ADP to ATP (energy production), significantly reducing electron flow through the electron transport chain. Anticancer agent. Shown to induce apoptosis/necroptosis in a variety of cell types, as well as autophagy. Shown to activate AMPK. Broad antifungal, antibiotic and nematocidal agent.\|Potent mitochondrial ATP synthase (ATPases (F0F1)) inhibitor, consequently leading to inhibition of oxidative phosphorylation (OXPHOS). Useful agent for immunometabolism research. Inhibits ATP synthase by blocking its proton channel (F0 subunit), which is necessary for oxidative phosphorylation of ADP to ATP (energy production), significantly reducing electron flow through the electron transport chain. Anticancer agent. Shown to induce apoptosis/necroptosis in a variety of cell types, as well as autophagy. Shown to activate AMPK. Broad antifungal, antibiotic and nematocidal agent.
Molecular Formula	C45H74O11
Alias Names	MCH 32
Product Type	Chemicals & Biochemicals
Purity	>95%
Shipping Information	RT
Size	1 mg
Solubility	Soluble in DMSO (20mg/ml), ethanol (20mg/ml) or DMF (20mg/ml).
Stability	Stable for at least 2 years after receipt when stored at -20°C.
Storage	-20°C, 4°C
Technical Specifications	Chemical. CAS: 579-13-5. Formula: C45H74O11. MW: 791.1. Synthetic. Originally isolated from Streptomyces diastatochromogenes. Potent mitochondrial ATP synthase (ATPases (F1F0)) inhibitor, consequently leading to inhibition of oxidative phosphorylation (OXPHOS). Useful agent for immunometabolism research. Inhibits ATP synthase by blocking its proton channel (F0 subunit), which is necessary for oxidative phosphorylation of ADP to ATP (energy production), significantly reducing electron flow through the electron transport chain. Anticancer agent. Shown to induce apoptosis/necroptosis in a variety of cell types, as well as autophagy. Shown to activate AMPK. Broad antifungal, antibiotic and nematocidal agent.
Product Page Updated	2024-02-01T08:25:01.492Z

Documentation

Datasheet

MSDS

References

Oligomycin, a new antifungal antibiotic: R.M. Smith, et al.; Antibiot. Chemother. 4, 962 (1954) | The use of oligomycin as an inhibitor of oxidative phosphorylation: F. Huijing & E.C. Slater; J. Biochem. 49, 493 (1961) | Inhibitors of the ATP synthethase system: P.E. Linnett & R.B. Beechey; Methods Enzymol. 55, 472 (1979) | Apoptolidin, a selective cytotoxic agent, is an inhibitor of F0F1-ATPase: A.R. Salomon, et al.; Chem. Biol. 8, 71 (2001) | Oligomycin, inhibitor of the F0 part of H+-ATP-synthase, suppresses the TNF-induced apoptosis: L.A. Shchepina, et al.; Oncogene 21, 8149 (2002) | Activation of AMP-Activated Protein Kinase Leads to the Phosphorylation of Elongation Factor 2 and an Inhibition of Protein Synthesis: S. Horman, et al.; Curr. Biol. 12, 1419 (2002) | Down-regulation of mitochondrial F1F0-ATP synthase in human colon cancer cells with induced 5-fluorouracil resistance: Y.K. Shin, et al.; Cancer Res. 65, 3162 (2005) | Oligomycin A induces autophagy in the IPLB-LdFB insect cell line: G. Tettamanti, et al.; Cell Tissue Res. 326, 179 (2006) | Age-dependent cell death and the role of ATP in hydrogen peroxide-induced apoptosis and necrosis: N. Miyoshi, et al.; PNAS 103, 1727 (2006) | A new strain of Streptomyces avermitilis produces high yield of oligomycin A with potent anti-tumor activity on human cancer cell lines in vitro: X. Lin, et al.; Appl. Microbiol. Biotechnol. 81, 839 (2009) | Mitochondrial proton and electron leaks: M. Jastroch, et al.; Essays Biochem. 47, 53 (2010) | Mitochondria as new therapeutic targets for eradicating cancer stem cells: Quantitative proteomics and functional validation via MCT1/2 inhibition: R. Lamb, et al.; Oncotarget 5, 11029 (2014) | A guide to immunometabolism for immunologists: L.A. O'Neill, et al.; Nat. Rev. Immunol. 16, 553 (2016) (Review) | The phenotype of peritoneal mouse macrophages depends on the mitochondria and ATP/ADP homeostasis: W. Chen, et al.; Cell Immunol. 324, 1 (2018) | Role of mitochondrial function in the invasiveness of human colon cancer cells: C.S. Lin, et al.; Oncol. Rep. 39, 316 (2018)

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