Article No
AG-CN2-0517-M010
CAS No | 579-13-5 |
MW | 791.1 |
Article No | AG-CN2-0517-M010 |
Country Availability | SE, FI, DK, NO, IS, EE, LV, LT |
Description | Oligomycin A |
Supplier | Adipogen Life Sciences |
Format | Powder |
Notes | Chemical. CAS: 579-13-5. Formula: C45H74O11. MW: 791.1. Synthetic. Originally isolated from Streptomyces diastatochromogenes. Potent mitochondrial ATP synthase (ATPases (F1F0)) inhibitor, consequently leading to inhibition of oxidative phosphorylation (OXPHOS). Useful agent for immunometabolism research. Inhibits ATP synthase by blocking its proton channel (F0 subunit), which is necessary for oxidative phosphorylation of ADP to ATP (energy production), significantly reducing electron flow through the electron transport chain. Anticancer agent. Shown to induce apoptosis/necroptosis in a variety of cell types, as well as autophagy. Shown to activate AMPK. Broad antifungal, antibiotic and nematocidal agent.|Potent mitochondrial ATP synthase (ATPases (F0F1)) inhibitor, consequently leading to inhibition of oxidative phosphorylation (OXPHOS). Useful agent for immunometabolism research. Inhibits ATP synthase by blocking its proton channel (F0 subunit), which is necessary for oxidative phosphorylation of ADP to ATP (energy production), significantly reducing electron flow through the electron transport chain. Anticancer agent. Shown to induce apoptosis/necroptosis in a variety of cell types, as well as autophagy. Shown to activate AMPK. Broad antifungal, antibiotic and nematocidal agent. |
Molecular Formula | C45H74O11 |
Alias Names | MCH 32 |
Product Type | Chemicals & Biochemicals |
Purity | >95% |
Shipping Information | RT |
Size | 10 mg |
Solubility | Soluble in DMSO (20mg/ml), ethanol (20mg/ml) or DMF (20mg/ml). |
Stability | Stable for at least 2 years after receipt when stored at -20°C. |
Storage | -20°C, 4°C |
Technical Specifications | Chemical. CAS: 579-13-5. Formula: C45H74O11. MW: 791.1. Synthetic. Originally isolated from Streptomyces diastatochromogenes. Potent mitochondrial ATP synthase (ATPases (F1F0)) inhibitor, consequently leading to inhibition of oxidative phosphorylation (OXPHOS). Useful agent for immunometabolism research. Inhibits ATP synthase by blocking its proton channel (F0 subunit), which is necessary for oxidative phosphorylation of ADP to ATP (energy production), significantly reducing electron flow through the electron transport chain. Anticancer agent. Shown to induce apoptosis/necroptosis in a variety of cell types, as well as autophagy. Shown to activate AMPK. Broad antifungal, antibiotic and nematocidal agent. |
Product Page Updated | 2024-02-01T08:25:01.492Z |