(S)-CR8

Article No AG-CR1-0040-M001
Product Type Chemicals & Biochemicals
Research Area Cell Death
Format Powder
Size 1 mg

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Specifications

CAS No 1084893-56-0
MW 431.5
Country Availability DK, EE, FI, IS, LT, LV, NO, SE
Data Sheet Link https://www.adipogen.com/productmanagement/resource/download/type/sheet/id/11286
Description (S)-CR8
Supplier Adipogen Life Sciences
Notes Potent and selective cyclin-dependent kinase (CDK) 1, 2, 5, 7 and 9 inhibitor. Apoptosis inducer. Glycogen synthase kinase (GSK-3alpha/beta) inhibitor.
Molecular Formula C24H29N7O
Alias Names 2-(S)-(1-Ethyl-2-hydroxyethylamino)-6-(4-(2-pyridyl)benzyl)-9-isopropylpurine
Purity >98% (NMR)
References CR8, a potent and selective, roscovitine-derived inhibitor of cyclin-dependent kinases: K. Bettayeb, et al.; Oncogene 27, 5797 (2008) | CDK inhibitors roscovitine and CR8 trigger Mcl-1 down-regulation and apoptotic cell death in neuroblastoma cells: K. Bettayeb, et al.; Genes Cancer 1, 369 (2010) | CDK inhibitors R-roscovitine and S-CR8 effectively block renal and hepatic cystogenesis in an orthologous model of ADPKD: N.O. Bukanov, et al.; Cell Cycle 11, 4040 (2012) | Pharmacokinetics and biodistribution of the cyclin-dependent kinase inhibitor -CR8- in mice: H. Sallam, et al.; BMC Pharmacol. Toxicol. 14, 50 (2013) | Inhibition of NF-kappaB-mediated signaling by the cyclin-dependent kinase inhibitor CR8 overcomes prosurvival stimuli to induce apoptosis in chronic lymphocytic leukemia cells: E. Cosimo, et al.; Clin. Cancer Res. 19, 2393 (2013)
Solubility Soluble in DMSO or 100% ethanol.
Storage -20°C
Technical Specifications Chemical. CAS: 1084893-56-0. Formula: C24H29N7O. MW: 431.5. Potent and selective cyclin-dependent kinase (CDK) 1, 2, 5, 7 and 9 inhibitor. Apoptosis inducer. Glycogen synthase kinase (GSK-3alpha/beta) inhibitor.
Product Page Updated 2019-01-09T14:34:57.552Z

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