Article No
AG-CR1-0071-M001
CAS No | 3895-92-9 |
MW | 383.8 |
Article No | AG-CR1-0071-M001 |
Country Availability | SE, FI, DK, NO, IS, EE, LV, LT |
Description | Chelerythrine chloride |
Supplier | Adipogen Life Sciences |
Format | Powder |
Notes | Cell permeable potent inhibitor of protein kinase C. Does not inhibit tyrosine protein kinases, cAMP-dependent protein kinase or calcium/calmodulin-dependent protein kinase [1, 5]. Antiplatelet, anti-inflammatory, antibacterial and antitumor compound [1, 2, 9, 12, 15]. Apoptosis inducer in cancer cells in vitro and in vivo [3, 9]. Activates MAPK and JUNK signaling pathways [4, 8]. Affects translocation of PKC from cytosol to plasma membrane [6]. Neurite outgrowth stimulator [7]. Inhibits binding of BclXL to Bak (IC50 = 1.5 µM) or Bad proteins and stimulates apoptosis in several cancer cell lines [10, 13]. Blocks human P2X7 receptor [11]. Induces cell cycle arrest in G1 phase [14]. Specific cyclooxygenase-2 inhibitor [15].|Chemical. CAS: 3895-92-9. Formula: C21H18ClNO4. MW: 383.8. Cell permeable potent inhibitor of protein kinase C. Does not inhibit tyrosine protein kinases, cAMP-dependent protein kinase or calcium/calmodulin-dependent protein kinase. Antiplatelet, anti-inflammatory, antibacterial and antitumor compound. Apoptosis inducer in cancer cells in vitro and in vivo. Activates MAPK and JUNK signaling pathways. Affects translocation of PKC from cytosol to plasma membrane. Neurite outgrowth stimulator. Inhibits binding of BclXL to Bak (IC50 = 1.5 µM) or Bad proteins and stimulates apoptosis in several cancer cell lines. Blocks human P2X7 receptor. Induces cell cycle arrest in G1 phase. Specific cyclooxygenase-2 inhibitor. |
Molecular Formula | C21H18ClNO4 |
Alias Names | NSC 36405; 1,2-Dimethoxy-N-methyl-[1,3]benzodioxolo[5,6-c]phenanthridinium chloride |
Product Type | Chemicals & Biochemicals |
Purity | >98% |
Research area | Cell Death |
Shipping Information | RT |
Size | 1 mg |
Solubility | Soluble in DMSO, ethanol, methanol or water (2mg/ml warm). |
Stability | Stable for at least 2 years after receipt when stored at -20°C. |
Storage | -20°C, 4°C |
Technical Specifications | Chemical. CAS: 3895-92-9. Formula: C21H18ClNO4. MW: 383.8. Cell permeable potent inhibitor of protein kinase C. Does not inhibit tyrosine protein kinases, cAMP-dependent protein kinase or calcium/calmodulin-dependent protein kinase. Antiplatelet, anti-inflammatory, antibacterial and antitumor compound. Apoptosis inducer in cancer cells in vitro and in vivo. Activates MAPK and JUNK signaling pathways. Affects translocation of PKC from cytosol to plasma membrane. Neurite outgrowth stimulator. Inhibits binding of BclXL to Bak (IC50 = 1.5 µM) or Bad proteins and stimulates apoptosis in several cancer cell lines. Blocks human P2X7 receptor. Induces cell cycle arrest in G1 phase. Specific cyclooxygenase-2 inhibitor. |
Product Page Updated | 2024-02-01T08:25:01.492Z |