Article No
AG-CR1-3597-M100
Specifications
| CAS No | 5142-23-4 |
| MW | 149.2 |
| Article No | AG-CR1-3597-M100 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT |
| Description | 3-Methyladenine |
| Supplier | Adipogen Life Sciences |
| Format | Powder |
| Notes | Chemical. CAS: 5142-23-4. Formula: C6H7N5. MW: 149.2. Potent cell permeable and selective inhibitor of phosphatidyl-inositol 3-kinase (PI3K). Blocks class I, class II and class III PI3Ks, including some downstream targets. Blocks class I PI3K persistently and class III PI3K transiently. Induces autophagy under nutrient-rich conditions and inhibits starvation-induced autophagy due to differential effects on class I versus class III PI3 kinase. Shows some limited Vps34 preference in vitro compared to PtdIns3Kgamma. However, it is typically employed in cellular studies at a concentration of 10 mM, which can inhibit all PtdIns3Ks. Can target other kinases and affect other cellular processes, such as glycogen metabolism, lysosomal acidification, endocytosis and mitochondrial permeability transition. Anticancer compound. Neuroprotective. PKA-activation dependent lipolytic agent. Enhances ATGL-dependent hydrolysis of triacylglycerols.|Potent cell permeable and selective inhibitor of phosphatidyl-inositol 3-kinase (PI3K) [1, 7, 8]. Blocks class I, class II and class III PI3Ks, including some downstream targets [8]. Blocks class I PI3K persistently and class III PI3K transiently [7]. Induces autophagy under nutrient-rich conditions and inhibits starvation-induced autophagy due to differential effects on class I versus class III PI3 kinase [5, 7]. Shows some limited Vps34 preference in vitro compared to PtdIns3Kgamma. However, it is typically employed in cellular studies at a concentration of 10 mM, which can inhibit all PtdIns3Ks [8]. Can target other kinases and affect other cellular processes, such as glycogen metabolism, lysosomal acidification, endocytosis and mitochondrial permeability transition [2-4]. Anticancer compound [6, 10, 12]. Neuroprotective [9, 11]. PKA-activation dependent lipolytic agent. Enhances ATGL-dependent hydrolysis of triacylglycerols [13]. |
| Molecular Formula | C6H7N5 |
| Alias Names | 3-MA; 3MeA; 6-Amino-3-methylpurine; NSC 66389 |
| Product Type | Chemicals & Biochemicals |
| Purity | >98% |
| Research area | Cell Death |
| Shipping Information | RT |
| Size | 100 mg |
| Solubility | Soluble in DMSO, DMF, ethanol or water. |
| Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Storage | -20°C, 4°C |
| Technical Specifications | Chemical. CAS: 5142-23-4. Formula: C6H7N5. MW: 149.2. Potent cell permeable and selective inhibitor of phosphatidyl-inositol 3-kinase (PI3K). Blocks class I, class II and class III PI3Ks, including some downstream targets. Blocks class I PI3K persistently and class III PI3K transiently. Induces autophagy under nutrient-rich conditions and inhibits starvation-induced autophagy due to differential effects on class I versus class III PI3 kinase. Shows some limited Vps34 preference in vitro compared to PtdIns3Kgamma. However, it is typically employed in cellular studies at a concentration of 10 mM, which can inhibit all PtdIns3Ks. Can target other kinases and affect other cellular processes, such as glycogen metabolism, lysosomal acidification, endocytosis and mitochondrial permeability transition. Anticancer compound. Neuroprotective. PKA-activation dependent lipolytic agent. Enhances ATGL-dependent hydrolysis of triacylglycerols. |
| Product Page Updated | 2024-02-01T08:25:01.492Z |
