Article No
AG-CR1-3603-M005
Specifications
| CAS No | 300815-04-7 |
| MW | 438.7 |
| Article No | AG-CR1-3603-M005 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT |
| Description | Apcin |
| Supplier | Adipogen Life Sciences |
| Format | Powder |
| Notes | Cell permeable compound capable of slowing anaphase-promoting complex/cyclosome (APC/C)-dependent proteolysis. Inhibitor of the ubiquitin ligase activity of the APC/C by inhibiting substrate binding to Cdc20. Distinct mechanism of action than proTAME. Blocks mitotic exit only modestly when used alone in cultured cells. A strong synergistic effect is observed when Apcin and proTAME are used simultaneously, providing a more robust mitotic arrest. This may be very beneficial when treating cells that do not efficiently convert proTAME to its active parent compound (TAME) or if experiments demand strong APC/C inhibition.|Chemical. CAS: 300815-04-7. Formula: C13H14Cl3N7O4. MW: 438.7. Cell permeable compound capable of slowing anaphase-promoting complex/cyclosome (APC/C)-dependent proteolysis. Inhibitor of the ubiquitin ligase activity of the APC/C by inhibiting substrate binding to Cdc20. Distinct mechanism of action than proTAME. Blocks mitotic exit only modestly when used alone in cultured cells. A strong synergistic effect is observed when Apcin and proTAME are used simultaneously, providing a more robust mitotic arrest. This may be very beneficial when treating cells that do not efficiently convert proTAME to its active parent compound (TAME) or if experiments demand strong APC/C inhibition. |
| Molecular Formula | C13H14Cl3N7O4 |
| Alias Names | Anaphase Promoting Complex Inhibitor |
| Product Type | Chemicals & Biochemicals |
| Purity | >98% |
| Research area | Cell Death |
| Shipping Information | RT |
| Size | 5 mg |
| Solubility | Soluble in DMSO (20mM). |
| Stability | Stable for at least 1 year after receipt when stored at -20°C. |
| Storage | -20°C, 4°C |
| Substrate / Buffer | Soluble in DMSO (20mg/ml). |
| Technical Specifications | Chemical. CAS: 300815-04-7. Formula: C13H14Cl3N7O4. MW: 438.7. Cell permeable compound capable of slowing anaphase-promoting complex/cyclosome (APC/C)-dependent proteolysis. Inhibitor of the ubiquitin ligase activity of the APC/C by inhibiting substrate binding to Cdc20. Distinct mechanism of action than proTAME. Blocks mitotic exit only modestly when used alone in cultured cells. A strong synergistic effect is observed when Apcin and proTAME are used simultaneously, providing a more robust mitotic arrest. This may be very beneficial when treating cells that do not efficiently convert proTAME to its active parent compound (TAME) or if experiments demand strong APC/C inhibition. |
| Product Page Updated | 2024-02-01T08:25:01.492Z |
