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AEBSF . hydrochloride

Chemicals & Biochemicals

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Article No

AG-CR1-3610-M050

Size

50 mg

Shipping Information

Article No

AG-CR1-3610-M050

Size

50 mg

Specifications

CAS No	30827-99-7
MW	203.2 . 36.5
Article No	AG-CR1-3610-M050
Country Availability	SE, FI, DK, NO, IS, EE, LV, LT
Description	AEBSF . hydrochloride
Supplier	Adipogen Life Sciences
Format	Powder
Notes	Chemical. CAS: 30827-99-7. Formula: C8H10FNO2S . HCl. MW: 203.2 . 36.5. Synthetic. Water soluble, irreversible serine protease (chymotrypsin, kallikrein, plasmin, thrombin and trypsin) inhibitor. Stable, non-toxic alternative to PMSF. Potent, selective inhibitor of Site-1-protease (S1P). Used to characterize the downstream result of SREBP inhibition and its influence on cholesterol regulation by selectively inhibiting S1P. NAD(P)H oxidase inhibitor. Inhibits activation of TGFbeta and activates JNK and p38 MAP kinases. beta-Secretase inhibitor. Shown to inhibit beta-amyloid peptide production and enhance APP (amyloid precursor protein) secretion in several cell lines at millimolar concentrations.\|Water soluble, irreversible serine protease (chymotrypsin, kallikrein, plasmin, thrombin and trypsin) inhibitor. Stable, non-toxic alternative to PMSF. Potent, selective inhibitor of Site-1-protease (S1P). Used to characterize the downstream result of SREBP inhibition and its influence on cholesterol regulation by selectively inhibiting S1P. NAD(P)H oxidase inhibitor. Inhibits activation of TGFbeta and activates JNK and p38 MAP kinases. beta-Secretase inhibitor. Shown to inhibit beta-amyloid peptide production and enhance APP (amyloid precursor protein) secretion in several cell lines at millimolar concentrations.
Molecular Formula	C8H10FNO2S . HCl
Alias Names	4-(2-Aminoethyl)benzenesulfonylfluoride; Pefabloc SC
Product Type	Chemicals & Biochemicals
Purity	>98%
Research area	Metabolism
Shipping Information	RT
Size	50 mg
Solubility	Soluble in water or 100% ethanol.
Stability	Stable for at least 2 years after receipt when stored at -20°C.
Storage	-20°C, 4°C
Technical Specifications	Chemical. CAS: 30827-99-7. Formula: C8H10FNO2S . HCl. MW: 203.2 . 36.5. Synthetic. Water soluble, irreversible serine protease (chymotrypsin, kallikrein, plasmin, thrombin and trypsin) inhibitor. Stable, non-toxic alternative to PMSF. Potent, selective inhibitor of Site-1-protease (S1P). Used to characterize the downstream result of SREBP inhibition and its influence on cholesterol regulation by selectively inhibiting S1P. NAD(P)H oxidase inhibitor. Inhibits activation of TGFbeta and activates JNK and p38 MAP kinases. beta-Secretase inhibitor. Shown to inhibit beta-amyloid peptide production and enhance APP (amyloid precursor protein) secretion in several cell lines at millimolar concentrations.
Product Page Updated	2024-02-01T08:25:01.492Z

Documentation

Datasheet

MSDS

References

Irreversible enzyme inhibitors. 180. Irreversible inhibitors of the Cla component of complement derived from m-(phenoxypropoxy)benzamidine and phenoxyacetamide: B.R. Baker & M. Cory; J. Med. Chem. 14, 119 (1971) | Synthetic low molecular weight inhibitors of serum kallikrein: F. Markwardt, et al.; Biochem. Pharmacol. 23, 2247 (1974) | Inhibition of amyloid beta-protein production in neural cells by the serine protease inhibitor AEBSF: M. Citron, et al.; Neuron 17, 171 (1996) | Inhibition of NADPH oxidase activation by 4-(2-aminoethyl)-benzenesulfonyl fluoride and related compounds: V. Diatchuk, et al.; J. Biol. Chem. 272, 13292 (1997) | 4-(2-Aminoethyl)benzenesulfonyl fluoride attenuates tumor-necrosis-factor-alpha-induced blood-brain barrier opening: P. Megyeri, et al.; Eur. J. Pharmacol. 374, 207 (1999) | Irreversible inhibitors of serine, cysteine, and threonine proteases: J.C. Powers, et al.; Chem. Rev. 102, 4639 (2002) | A serine protease inhibitor prevents endoplasmic reticulum stress-induced cleavage but not transport of the membrane-bound transcription factor ATF6: T. Okada, et al.; J. Biol. Chem. 278, 31024 (2003) | Proteolytic activation of latent TGF-beta precedes caspase-3 activation and enhances apoptotic death of lung epithelial cells: V.T. Solovyan & J. Keski-Oja; J. Cell Physiol. 207, 445 (2006) | Serine protease inhibitor attenuates ovalbumin induced inflammation in mouse model of allergic airway disease: S. Saw, et al.; PLoS One 7, e41107 (2012)

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