Article No
AG-MR-C0014-M025
Specifications
| CAS No | 866893-90-5 |
| MW | 368.5 |
| Article No | AG-MR-C0014-M025 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT |
| Description | Aftin-4 |
| Supplier | Adipogen Life Sciences |
| Format | Powder |
| Notes | Chemical. CAS: 866893-90-5. Formula: C20H28N6O. MW: 368.5. Roscovitine-related purine with no activity on CDKs (used as control for roscovitine). Selectively and potently increases production of extracellular Abeta42 and decreases production of extracellular Abeta38 in cultured cells. Extracellular Abeta40 levels remain stable. Intracellular levels of these amyloids appear to remain stable. Alzheimer's Disease (AD) accelerator that interacts with VDAC1, prohibitin and mitofilin, possibly interfering with subcellular compartmentalization and lipid rafts properties, shifting gamma-secretase activity toward Abeta42 generation. Induces a reversible mitochondrial phenotype reminiscent of the one observed in AD brains. Tool to detect inhibitors of Aftin-induced actions (potential anti-AD compounds). Binds pyridoxal kinase.|Roscovitine-related purine with no activity on CDKs (used as control for roscovitine). Selectively and potently increases production of extracellular Abeta42 and decreases production of extracellular Abeta38 in cultured cells. Extracellular Abeta40 levels remain stable. Intracellular levels of these amyloids appear to remain stable. Alzheimer's Disease (AD) accelerator that interacts with VDAC1, prohibitin and mitofilin, possibly interfering with subcellular compartmentalization and lipid rafts properties, shifting gamma-secretase activity toward Abeta42 generation. Induces a reversible mitochondrial phenotype reminiscent of the one observed in AD brains. Tool to detect inhibitors of Aftin-induced actions (potential anti-AD compounds). Binds pyridoxal kinase. |
| Molecular Formula | C20H28N6O |
| Alias Names | N6-Methyl-(R)-roscovitine; Amyloid-beta Forty-Two Inducer 4 |
| Product Type | Chemicals & Biochemicals |
| Purity | >98% |
| Find out more about our research areas Biochemical, Immunology, Molecular Biology and Pathology | Neuroscience |
| Shipping Information | RT |
| Size | 25 mg |
| Solubility | Soluble in DMSO or ethanol. |
| Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Storage | -20°C, 4°C |
| Technical Specifications | Chemical. CAS: 866893-90-5. Formula: C20H28N6O. MW: 368.5. Roscovitine-related purine with no activity on CDKs (used as control for roscovitine). Selectively and potently increases production of extracellular Abeta42 and decreases production of extracellular Abeta38 in cultured cells. Extracellular Abeta40 levels remain stable. Intracellular levels of these amyloids appear to remain stable. Alzheimer's Disease (AD) accelerator that interacts with VDAC1, prohibitin and mitofilin, possibly interfering with subcellular compartmentalization and lipid rafts properties, shifting gamma-secretase activity toward Abeta42 generation. Induces a reversible mitochondrial phenotype reminiscent of the one observed in AD brains. Tool to detect inhibitors of Aftin-induced actions (potential anti-AD compounds). Binds pyridoxal kinase. |
| Product Page Updated | 2024-02-01T08:25:01.492Z |
