Article No
AM2204b-ev
Specifications
| MW | 55103 |
| NCBI Number | NP_004955.2 |
| Accession Number | Q13547 |
| Application | WB |
| Article No | AM2204b-ev |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT, FO, GL |
| Clone | 1061CT1.3.1 |
| Clone Type | monoclonal |
| Conjugation | Unconjugated |
| Description | HDAC1 Antibody |
| Recommended Dilution | 1:1000 |
| Supplier | Abgent |
| Entrez Gene ID | 3065 |
| Format | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Euglobin precipitation followed by dialysis against PBS. |
| Isotype | IgM, k |
| Keywords | Crown Antibodies;Primary Antibodies;Cardiovascular;Cell Biology;Signal Transduction |
| Notes | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B. Component a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. |
| Alias Names | Histone deacetylase 1, HD1, HDAC1, RPD3L1 |
| Product Type | Antibodies Primary |
| Size | 80 µl |
| Source / Host | mouse |
| Species Reactivity | human |
| Substrate / Buffer | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Euglobin precipitation followed by dialysis against PBS. |
| Technical Specifications | Purified His-tagged HDAC1 protein was used to produced this monoclonal antibody. |
| Product Page Updated | 2023-11-23T14:38:54.086Z |
