Article No
AMB-WAUOMI-100
MW | 114kDa |
Application | WB, ELISA, FC |
Article No | AMB-WAUOMI-100 |
Biosite Brand | Biosite mAb |
Country Availability | all |
Clone | 10F6 |
Clone Type | monoclonal |
Conjugation | Unconjugated |
Description | ITGA5 Primary Antibody |
Supplier | Nordic Biosite |
Entrez Gene ID | 3678 |
Format | Ascitic fluid containing 0.03% sodium azide. |
Immunogen | Purified recombinant fragment of human ITGA5 expressed in E. Coli. |
Isotype | IgG2a |
Notes | The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. Integrin alpha 5 is a heterodimer that associates noncovalently with CD29/integrin beta 1 subunit to form the alpha-5-beta-1 very late antigen (VLA-5) complex. VLA-5 is a fibronectin receptor that is expressed on thymocytes, T-cells, monocytes and platelets. It is also found on very early B-cells and activated B-cells. VLA-5-mediated binding to fibronectin sends a costimulatory signal to T-cells and enhances Fc-gamma-R- and complement receptor-mediated phago-cytosis. It is also involved in monocyte migration into extracellular tissues. |
Alias Names | FNRA; CD49e; VLA5A; ITGA5 |
Previous Article No | AMB-8422 |
Product Type | Antibodies Primary |
Protocol | ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: 1/200 - 1/1000; FCM: 1/200 - 1/400 |
Size | 100µl |
Source / Host | mouse |
Species Reactivity | human |
Storage | 4°C -20°C for long term storage |
Substrate / Buffer | Ascitic fluid containing 0.03% sodium azide. |
Technical Specifications | ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: 1/200 - 1/1000; FCM: 1/200 - 1/400 |
Product Page Updated | 2024-01-25T14:27:22.065Z |