Article No
ANC-353-020
Application | Block, ELISA, FC, IHC, WB |
Article No | ANC-353-020 |
Country Availability | SE, FI, DK, NO, IS, EE, LV, LT |
Clone | 24-31 |
Clone Type | monoclonal |
Conjugation | Unconjugated |
Description | anti-CD40L [CD154] (human), mAb (24-31) |
Supplier | Adipogen Life Sciences |
Format | Liquid |
Immunogen | Human sgp39 fusion protein. |
Isotype | IgG1 |
Notes | Human CD154 (CD40 ligand) is a member of the TNF family and is expressed on the surface of activated T cells. Interaction of CD154 and CD40 is essential for isotype switching in B cells. Known genetic defects that alter this interaction lead to impaired immune system function. CD154 has been shown to be hyperexpressed by B and T cells in SLE patients. CD154 has been reported to be expressed on vascular endothelial cells, smooth muscle cells and macrophages indicating a possible role for the CD40-CD154 immunoregulatory signaling mechanism during inflammation and immunity in atherogenesis.|Monoclonal Antibody. Isotype: Mouse IgG1. Clone: 24-31. Applications: ELISA, FACS, FUNC (Blocking), IHC, WB. 50 mM Sodium Phosphate pH 7.5, 100 mM Potassium Chloride, 150mM NaCl, 0.5% Gentamicin sulfate Human CD154 (CD40 ligand) is a member of the TNF family and is expressed on the surface of activated T cells. Interaction of CD154 and CD40 is essential for isotype switching in B cells. Known genetic defects that alter this interaction lead to impaired immune system function. CD154 has been shown to be hyperexpressed by B and T cells in SLE patients. CD154 has been reported to be expressed on vascular endothelial cells, smooth muscle cells and macrophages indicating a possible role for the CD40-CD154 immunoregulatory signaling mechanism during inflammation and immunity in atherogenesis. |
Product Type | Antibodies Primary |
Find out more about our research areas Biochemical, Immunology, Molecular Biology and Pathology | Immunology |
Shipping Information | BLUE ICE |
Size | 100 µg |
Source / Host | mouse |
Species Reactivity | human, mammals |
Stability | Stable for at least 1 year after receipt when stored at +4°C. |
Storage | 4°C |
Substrate / Buffer | 50 mM Sodium Phosphate pH 7.5, 100 mM Potassium Chloride, 150mM NaCl, 0.5% Gentamicin sulfate |
Technical Specifications | Monoclonal Antibody. Isotype: Mouse IgG1. Clone: 24-31. Applications: ELISA, FACS, FUNC (Blocking), IHC, WB. 50 mM Sodium Phosphate pH 7.5, 100 mM Potassium Chloride, 150mM NaCl, 0.5% Gentamicin sulfate Human CD154 (CD40 ligand) is a member of the TNF family and is expressed on the surface of activated T cells. Interaction of CD154 and CD40 is essential for isotype switching in B cells. Known genetic defects that alter this interaction lead to impaired immune system function. CD154 has been shown to be hyperexpressed by B and T cells in SLE patients. CD154 has been reported to be expressed on vascular endothelial cells, smooth muscle cells and macrophages indicating a possible role for the CD40-CD154 immunoregulatory signaling mechanism during inflammation and immunity in atherogenesis. |
Product Page Updated | 2024-02-01T08:25:01.492Z |