Article No
AP11975A
MeCP2 Antibody
MeCP2 Antibody (N-term S80)
Antibodies Primary
Specifications
| MW | 52441 |
| NCBI Number | NP_001104262.1;NP_004983.1 |
| Accession Number | P51608 |
| Application | FC, WB |
| Article No | AP11975A |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT, FO, GL |
| Clone | RB27934 |
| Clone Type | polyclonal |
| Conjugation | Unconjugated |
| Description | MeCP2 Antibody (N-term S80) |
| Recommended Dilution | 1:500 |
| Supplier | Abgent |
| Entrez Gene ID | 4204 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Isotype | IgG |
| Keywords | Primary Antibodies;Neuroscience |
| Notes | DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females. [provided by RefSeq]. |
| Alias Names | Methyl-CpG-binding protein 2, MeCp-2 protein, MeCp2, MECP2 |
| Product Type | Antibodies Primary |
| Research area | Neuroscience |
| Size | 400 µl |
| Source / Host | rabbit |
| Species Reactivity | human |
| Substrate / Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Technical Specifications | This MeCP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 58-87 amino acids from the N-terminal region of human MeCP2. |
| Product Page Updated | 2023-11-23T14:38:54.086Z |
